Metabolic measurement plays a critical role in aging research as the community seeks to understand the healthspan and lifespan trade-offs of the aging process. Recent integrated research from model animals to humans has applied indirect calorimetry to further understand the relationship of cardiovascular disease, insulin resistance, metabolic syndrome and diabetes to senescence. From such a research platform we can better consider which interventions can effectively mitigate age related disease.
- Precise calorimetry, food and water intake measurements
- High temporal resolution for circadian studies
- Instrumentation scales from Drosophila to human
- High-throughput and workflow efficiency
- GLP compliant solutions, animal safety focus
- Activity monitoring with Ethogram capability
Csóka, B., Koscsó, B., Törő, G., Kókai, E., Virág, L., Németh, Z. H., … & Haskó, G. (2014). A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation. Diabetes, 63(3), 850-866.
Icreverzi, A., de la Cruz, A. F., Van Voorhies, W. A., & Edgar, B. A. (2012). Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress. Cell Cycle, 11(3), 554-68.
Lane, S. J., Frankino, W. A., Elekonich, M. M., & Roberts, S. P. (2014). The effects of age and lifetime flight behavior on flight capacity in Drosophila melanogaster. The Journal of experimental biology, 217(9), 1437-1443. [and see Controlled Atmospheres applications]
Stern, J. H., Kim, K., & Ramsey, J. J. (2012). The influence of Shc proteins and aging on whole body energy expenditure and substrate utilization in mice. PloS one, 7(11), e48790.
Wit, J., Sarup, P., Lupsa, N., Malte, H., Frydenberg, J., & Loeschcke, V. (2013). Longevity for free? Increased reproduction with limited trade-offs in Drosophila melanogaster selected for increased life span. Experimental gerontology, 48(3), 349-357.