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Slide Gerontology

Applications

Home/Applications/Biomedical Research/Gerontology
GerontologyJeff Richardson2022-03-25T10:15:02-07:00

Gerontology is the study of physical, mental, and social changes due to aging. Aging affects every aspect of physiology. Furthermore, genetics and behavior combine to affect aging and all of its effects; reduced cardiovascular capability, lower metabolism, weakened muscles and bones, and reduced cognition.

Metabolic and behavioral phenotyping plays a critical role in aging research as scientists  seek to understand the whys and hows of the aging process. The goals being to slow the aging process and increase the quality of life. Recent integrated research from model animals to humans has use metabolic and behavioral phenotyping to further understand the relationship of cardiovascular disease, insulin resistance, metabolic syndrome and diabetes to aging.

Important System Considerations

  • Precise calorimetry, food and water intake measurements
  • High temporal resolution for circadian studies
  • Instrumentation scales from Drosophila to human
  • High-throughput and workflow efficiency
  • GLP compliant solutions, animal safety focus
  • Activity monitoring with Ethogram capability

Sable Solutions

Drosophila Metabolic Screening System

Depending on the method used, Sable Drosophila metabolic screening systems are capable of measuring the metabolic rates of small groups of Drosophila, or even of individual Drosophila in real time. This unique ... (more)

MAVEn™ System for Small Insect Flow-Through Respirometry

The Sable MAVEn™ system is an integrated, compact 16-channel flow generator for small insect flow-through respirometry. Each flow is pushed through a sealed container holding a subject animal. The system automatically selects ... (more)

Promethion Core Behavioral System, Mouse

The Promethion Core Behavior Phenotyping System features the modular flexibility to support real-time behavioral studies in a home-cage setting. Capture a complete data-rich archive of behaviors with unbeatable temporal resolution. Second-by-second observations ... (more)

Promethion Core Metabolic System, Mouse

The Promethion Core High Definition Multiplexed Respirometry System for mice synchronously measures energy expenditure, RQ, VO2, VCO2 and activity.  The SableHD™ High Definition platform updates once per second for all sensors in ... (more)

Promethion High-Definition Room Calorimetry System

The Promethion High-Definition Room Calorimetry System is capable of synchronously recording all measured parameters in a completely traceable manner. Key components of this system include the GA-3m2 triple gas O2, CO2, and ... (more)

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Relevant Publications

Publications Filter - Applications Page - Gerontology

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15 Results Found (Showing 1 - 6)

Hypothalamic Menin regulates systemic aging and cognitive decline. Leng L, Yuan Z, Su Z, Chen Z, Yang S, Chen M, Zhuang K, Lin H, Sun H, Li H, Xue M, Xu J, Yan J, Chen Z, Yuan T, & Zhang J. PLOS Biology. 3/16/2023.

March 16, 2023 12:00 am Published by Brett Davis

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BCAA insufficiency leads to premature ovarian insufficiency via ceramide-induced elevation of ROS. Guo X, Zhu Y, Guo L, Qi Y, Liu X, Wang J, Zhang J, Cui L, Shi L, Wang Q, Liu C, Lu G, Liu Y, Li T, Hong S, Qin Y, Xiong X, Wu H, Huang L, Huang H, Gu C, Li B, & Li J. EMBO Molecular Medicine. 2/27/2023.

February 27, 2023 12:00 am Published by Brett Davis

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Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice. Hedges CP, Shetty B, Broome SC, MacRae C, Koutsifeli P, Buckels EJ, MacIndoe C, Boix J, Tsiloulis T, Matthews BG, Sinha S, Arendse M, Jaiswal JK, Mellor KM, Hickey AJR, Shepherd PR, & Merry TL. Nature Aging. 1/23/2023.

January 23, 2023 12:00 am Published by Brett Davis

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Mirabegron-induced brown fat activation does not exacerbate atherosclerosis in mice with a functional hepatic ApoE-LDLR pathway. Ying Z, van Eenige R, Beerepoot R, Boon MR, Kloosterhuis NJ, van de Sluis B, Bartelt A, Rensen PCN, & Kooijman S. Pharmacological Research. 1/1/2023.

January 1, 2023 12:00 am Published by Brett Davis

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Targeting the DP2 receptor alleviates muscle atrophy and diet-induced obesity in mice through oxidative myofiber transition. Ning H, Ren H, Zhao Y, Yin H, Gan Z, Shen Y, & Yu T. Journal of Cachexia. 10/27/2022.

October 27, 2022 12:00 am Published by Brett Davis

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APOEε4 1 and exercise interact to influence systemic and cerebral risk factors for dementia. Foley KE, Diemler CA, Hewes AA, Garceau DT, Sasner M, Howell GR. bioRxiv. 3/3/2022.

March 3, 2022 12:00 am Published by Brett Davis

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Sable Enables

Before configuring any system, we strive to understand your application. Our innovative instruments and analysis tools are then configured and customized for your application, providing you sound results and efficient workflow.

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