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Slide Gerontology

Applications

Home/Applications/Biomedical Research/Gerontology
GerontologyJeff Richardson2022-03-25T10:15:02-07:00

Gerontology is the study of physical, mental, and social changes due to aging. Aging affects every aspect of physiology. Furthermore, genetics and behavior combine to affect aging and all of its effects; reduced cardiovascular capability, lower metabolism, weakened muscles and bones, and reduced cognition.

Metabolic and behavioral phenotyping plays a critical role in aging research as scientists  seek to understand the whys and hows of the aging process. The goals being to slow the aging process and increase the quality of life. Recent integrated research from model animals to humans has use metabolic and behavioral phenotyping to further understand the relationship of cardiovascular disease, insulin resistance, metabolic syndrome and diabetes to aging.

Important System Considerations

  • Precise calorimetry, food and water intake measurements
  • High temporal resolution for circadian studies
  • Instrumentation scales from Drosophila to human
  • High-throughput and workflow efficiency
  • GLP compliant solutions, animal safety focus
  • Activity monitoring with Ethogram capability

Sable Solutions

Drosophila Metabolic Screening System

Depending on the method used, Sable Drosophila metabolic screening systems are capable of measuring the metabolic rates of small groups of Drosophila, or even of individual Drosophila in real time. This unique ... (more)

MAVEn™ System for Small Insect Flow-Through Respirometry

The Sable MAVEn™ system is an integrated, compact 16-channel flow generator for small insect flow-through respirometry. Each flow is pushed through a sealed container holding a subject animal. The system automatically selects ... (more)

Promethion Core Behavioral System, Mouse

The Promethion Core Behavior Phenotyping System features the modular flexibility to support real-time behavioral studies in a home-cage setting. Capture a complete data-rich archive of behaviors with unbeatable temporal resolution. Second-by-second observations ... (more)

Promethion Core Metabolic System, Mouse

The Promethion Core High Definition Multiplexed Respirometry System for mice synchronously measures energy expenditure, RQ, VO2, VCO2 and activity.  The SableHD™ High Definition platform updates once per second for all sensors in ... (more)

Promethion High-Definition Room Calorimetry System

The Promethion High-Definition Room Calorimetry System is capable of synchronously recording all measured parameters in a completely traceable manner. Key components of this system include the GA-3m2 triple gas O2, CO2, and ... (more)

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Relevant Publications

Publications Filter - Applications Page - Gerontology

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9 Results Found (Showing 1 - 6)

Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia-reperfusion damage. Alves FM, Kysenius K, Caldow MK, Hardee JP, Crouch PJ, Ayton S, Bush AI, Lynch GS, Koopman R. Journal of Cachexia, Sarcopenia and Muscle. 1/22/2021.

January 22, 2021 12:00 am Published by Brett Davis

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Muscle follistatin gene delivery increases muscle protein synthesis independent of periodical physical inactivity and fasting. Nissinen TA, Hentilä J, Fachada V, Lautaoja JH, Arja Pasternack A, Ritvos O, Kivelä R, Hulmi JJ. FASEB Journal. 11/27/2020.

November 27, 2020 12:00 am Published by Brett Davis

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Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice. Henneicke H, Kim S, Swarbrick MM, Li J, Gasparini SJ, Thai J, Foong D, Cavanagh LL, Fong-Yee C, Karsten E, Lin RCY, Cooper MS, Zhou H, Seibel MJ. Molecular Metabolism. 10/21/2020.

October 21, 2020 12:00 am Published by Brett Davis

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Developmental Exposure to a Mixture of Unconvential Oil and Gas Chemicals Increased Risk-Taking Behavior, Activity and Energy Expenditure in Aged Female Mice After a Metabolic Challenge. Balise VD, Cornelius-Green JN, Parmenter B, Baxter S, Kassotis CD, Rector RS, Thyfauilt JP, Paterlini S, Palanza P, Ruiz D, Sargis R, Nagel SC. Frontiers in Endocrinology. 7/25/2019.

July 25, 2019 12:00 am Published by Brett Davis

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Mice with myocyte deletion of vitamin D receptor have sacropenia and impaired muscle function. Girgis CM, Cha KM, So B, Tsang M, Chen J, Houweling PJ, Schindeler A, Stokes R, Swarbrick MM, Evesson FJ, Cooper ST, Gunton JE. Journal of Cachexia, Sarcopenia and Muscle. 6/21/2019.

June 21, 2019 12:00 am Published by Brett Davis

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Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O’Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raunbenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ. Nature Metabolism. 5/1/2019.

May 1, 2019 12:00 am Published by Brett Davis

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