Aging, Health and Lifespan Metabolic Studies

Metabolic measurement plays a critical role in aging research as the community seeks to understand the healthspan and lifespan trade-offs of the aging process. Recent integrated research from model animals to humans has applied indirect calorimetry to further understand the relationship of cardiovascular disease, insulin resistance, metabolic syndrome and diabetes to senescence. From such a research platform we can better consider which interventions can effectively mitigate age related disease.

Drosophila Metabolic Screening System

Depending on the method used, Sable Drosophila metabolic screening systems are capable of measuring the metabolic rates of small groups of Drosophila, or even of individual Drosophila in real time. This unique ... (more)

MAVEn™ System for Small Insect Flow-Through Respirometry

The Sable MAVEn™ system is an integrated, compact 16-channel flow generator for small insect flow-through respirometry. Each flow is pushed through a sealed container holding a subject animal. The system automatically selects ... (more)

Promethion Core Behavioral Phenotyping Mouse System

The Promethion Core Behavior Phenotyping System features the modular flexibility to support real-time behavioral studies in a home-cage setting. Capture a complete data-rich archive of behaviors with unbeatable temporal resolution. Second-by-second observations ... (more)

Promethion Core High-Definition Multiplexed Respirometry System for Mice

The Promethion Core High Definition Multiplexed Respirometry System for mice synchronously measures energy expenditure, RQ, VO2, VCO2 and activity. The SableHD™ High Definition platform updates once per second for all sensors in ... (more)

Promethion High-Definition Behavioral Phenotyping System for Rats

The Promethion line features the modular flexibility to support real-time behavioral studies in a home-cage setting with a small sample size or large-scale neurophysiological, pharmacokinetic and toxicological studies. Our high-definition behavioral phenotyping ... (more)

Promethion High-Definition Continuous Respirometry System for Mice

When high temporal resolution is critical, so is the selection of a “continuous” system for indirect calorimetry measurements. Similar to the Promethion multiplexed systems, this high-definition continuous system for mice combines ultra-high ... (more)

Promethion High-Definition Continuous Respirometry System for Rats

Promethion High-Definition Multiplexed Respirometry System for Rats

The Promethion High Definition Multiplexed Respirometry System for rats synchronously measures energy expenditure, RQ, VO2, VCO2 and activity. High definition is fundamentally resolution with depth of field. Sable’s Promethion digital platform updates ... (more)

Promethion High-Definition Room Calorimetry System

The Promethion High-Definition Room Calorimetry System is capable of synchronously recording all measured parameters in a completely traceable manner. Key components of this system include the GA-3m2 triple gas O2, CO2, and ... (more)

Our systems are highly customizable for a broad range of applications. Let us help configure a system to meet your specific research needs.

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Relevant Publications

Csóka, B., Koscsó, B., Törő, G., Kókai, E., Virág, L., Németh, Z. H., … & Haskó, G. (2014). A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation. Diabetes, 63(3), 850-866.

Icreverzi, A., de la Cruz, A. F., Van Voorhies, W. A., & Edgar, B. A. (2012). Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress. Cell Cycle, 11(3), 554-68.

Lane, S. J., Frankino, W. A., Elekonich, M. M., & Roberts, S. P. (2014). The effects of age and lifetime flight behavior on flight capacity in Drosophila melanogaster. The Journal of experimental biology, 217(9), 1437-1443. [and see Controlled Atmospheres applications]

Stern, J. H., Kim, K., & Ramsey, J. J. (2012). The influence of Shc proteins and aging on whole body energy expenditure and substrate utilization in mice. PloS one, 7(11), e48790.

Wit, J., Sarup, P., Lupsa, N., Malte, H., Frydenberg, J., & Loeschcke, V. (2013). Longevity for free? Increased reproduction with limited trade-offs in Drosophila melanogaster selected for increased life span. Experimental gerontology, 48(3), 349-357.