Metabolic measurement plays a critical role in aging research as the community seeks to understand the healthspan and lifespan trade-offs of the aging process. Recent integrated research from model animals to humans has applied indirect calorimetry to further understand the relationship of cardiovascular disease, insulin resistance, metabolic syndrome and diabetes to senescence. From such a research platform we can better consider which interventions can effectively mitigate age related disease.

Salient Features

  • Precise calorimetry, food and water intake measurements
  • High temporal resolution for circadian studies
  • Instrumentation scales from Drosophila to human
  • High-throughput and workflow efficiency
  • GLP compliant solutions, animal safety focus
  • Activity monitoring with Ethogram capability

Sable Solutions

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IMPORTANT MESSAGE REGARDING COVID-19 OUTBREAK Concerning the rapidly evolving spread of the coronavirus disease (COVID-19):  We want our customers and fellow researchers to know that Sable Systems is currently continuing our day-to-day ... Read More

Promethion High-Definition Room Calorimetry System

The Promethion High-Definition Room Calorimetry System is capable of synchronously recording all measured parameters in a completely traceable manner. Key components of this system include the GA-3m2 triple gas O2, CO2, and ... Read More

Promethion High-Definition Behavioral Phenotyping System for Mice

The Promethion line features the modular flexibility to support real-time behavioral studies in a home-cage setting with a small sample size or large-scale neurophysiological, pharmacokinetic and toxicological studies. Our high-definition behavioral phenotyping ... Read More

Promethion High-Definition Behavioral Phenotyping System for Rats

The Promethion line features the modular flexibility to support real-time behavioral studies in a home-cage setting with a small sample size or large-scale neurophysiological, pharmacokinetic and toxicological studies. Our high-definition behavioral phenotyping ... Read More

Promethion High-Definition Continuous Respirometry System for Mice

When high temporal resolution is critical, so is the selection of a “continuous” system for indirect calorimetry measurements. Similar to the Promethion multiplexed systems, this high-definition continuous system for mice combines ultra-high ... Read More

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Relevant Publications

Csóka, B., Koscsó, B., Törő, G., Kókai, E., Virág, L., Németh, Z. H., … & Haskó, G. (2014). A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation. Diabetes, 63(3), 850-866.

Icreverzi, A., de la Cruz, A. F., Van Voorhies, W. A., & Edgar, B. A. (2012). Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress. Cell Cycle, 11(3), 554-68.

Lane, S. J., Frankino, W. A., Elekonich, M. M., & Roberts, S. P. (2014). The effects of age and lifetime flight behavior on flight capacity in Drosophila melanogaster. The Journal of experimental biology, 217(9), 1437-1443. [and see Controlled Atmospheres applications]

Stern, J. H., Kim, K., & Ramsey, J. J. (2012). The influence of Shc proteins and aging on whole body energy expenditure and substrate utilization in mice. PloS one, 7(11), e48790.

Wit, J., Sarup, P., Lupsa, N., Malte, H., Frydenberg, J., & Loeschcke, V. (2013). Longevity for free? Increased reproduction with limited trade-offs in Drosophila melanogaster selected for increased life span. Experimental gerontology, 48(3), 349-357.