Metabolic Phenotyping

Understanding the subtle or complex indicators of physiological trade-offs in an animal’s health or lifespan involves consideration of energy balance, food preference, environmental factors and animal behavior. Sable Systems supports the metabolic phenotyping community’s efforts to establish relevant standards for model animal calorimetry phenotyping studies. Sable has focused our years of innovative experience and scientific expertise to generate confidence in translational results that lead to the causes or cures of debilitating diseases such as diabetes, obesity, and cancer.

Precise acquisition of metabolic data
High temporal resolution for metabolic rate (MR), respiratory quotent (RQ), and resting energy requirements (RER)
Second by second quantification of gross and fine motor activity.
Differentiate between food uptake and food stashing
Differentiate between large ingested meals and micro meals
Interchangeable instrumentation between mouse and rat cages
Designed for animal safety, stress reduction and optimal enrichment including 15 air exchanges per cage per hour as per IACUC standards.

Promethion Core High-Definition Multiplexed Respirometry System for Mice

The Promethion Core High Definition Multiplexed Respirometry System for mice synchronously measures energy expenditure, RQ, VO2, VCO2 and activity. The SableHD™ High Definition platform updates once per second for all sensors in ... (more)

Promethion Line

Promethion systems capture synchronized metabolic and behavioral information, yielding a highly-resolved and uniquely rich data stream. We offer multiplexed systems with multiple cages sharing a gas analyzer chain, offering cycle times up ... (more)

Relevant Publications

Bornstein, S., Brown, S. A., Le, P. T., Wang, X., DeMambro, V., Horowitz, M. C., … & Rosen, C. J. (2014). FGF-21 and Skeletal Remodeling During and After Lactation in C57BL6 Mice. Endocrinology.

Cappel, D. A., Palmisano, B. T., Emfinger, C. H., Martinez, M. N., McGuinness, O. P., & Stafford, J. M. (2013). Cholesteryl ester transfer protein protects against insulin resistance in obese female mice. Molecular metabolism, 2(4), 457-467.

Cappel, D. A. (2014). Metabolic Health with Obesity: A Novel Role for Cholesteryl Ester Transfer Protein (Doctoral dissertation, Vanderbilt University).

Kaiyala, K. J., Morton, G. J., Thaler, J. P., Meek, T. H., Tylee, T., Ogimoto, K., & Wisse, B. E. (2012). Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice. PloS one, 7(8), e41473.

Motyl, K. J., Bishop, K. A., DeMambro, V. E., Bornstein, S. A., Le, P., Kawai, M., … & Rosen, C. J. (2013). Altered thermogenesis and impaired bone remodeling in Misty mice. Journal of Bone and Mineral Research, 28(9), 1885-1897.

Luo, Y., , Burrington, C. M., Graff, E. C., Zhang, J., Judd, R. L., Suksaranjit, P., Kaewpoowat, Q., Davenport, S. K., O’Neill, A. M., Greene, M. W. (2015). Metabolic phenotype and adipose and liver features in the high fat Western diet-induced mouse model of obesity-linked NAFLD. American Journal of Physiology – Endocrinology and Metabolism, DOI: 10.1152/ajpendo.00319.2015

Corder, K. R., Schaeffer, P. J. (2015) Summit metabolic rate exhibits phenotypic flexibility with migration, but not latitude in a neotropical migrant, Parkesia noveboracensis. Journal of Ornithology, 156(2), 547-550.