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So far sable_admin has created 19 blog entries.

The “Deep Data Field System” in Metabolic Phenotyping

Data from a metabolic phenotyping system can be rigidly determined by the parameters entered at the time of the experiment (as with legacy systems), or the data can be a rich mine of information, with complete post-hoc analytical flexibility (as with Promethion). The latter approach allows extraction of experimental data, the need for which was not [...]

Published on January 29th, 2013|Founder's Blog|

Activity Metabolism Measurements Made Easy in Metabolic Phenotyping

One of the classic controversies in the field of metabolic science is the effect of activity on overall energy expenditure. As a comparative physiologist with a long-standing interest in energetics (and several papers published in that field), I find this controversy to be particularly strange, especially because some respectable and intelligent people will politely insist [...]

Published on October 30th, 2012|Founder's Blog|

How Multiplexing Distorts Metabolic Phenotyping Data

Multiplexing metabolic signals causes significant data distortion. This post explains how, and gives you access to an amazing, interactive tool for exploring the metabolic data distortions produced by this practically universally-used technique! To save cost, almost all metabolic phenotyping systems multiplex their gas analyzers, so that the air streams from the metabolic chambers are analyzed in succession. [...]

Published on September 11th, 2012|Founder's Blog|

Three reasons for misleading gas analyzer accuracy specifications

A funny thing happened on my way to helping a colleague make sense of the specifications of a metabolic phenotyping system. There were many strange things to mull over. Not the least of these were oxygen and carbon dioxide analyzer accuracy specifications that appeared to be the product of smoke, mirrors, and absinthe-infused coca tea [...]

Published on August 29th, 2012|Founder's Blog|

Data Visualizations you haven’t Seen Before…

OK, imagine a mouse in a cage. With Promethion, you can monitor that mouse's position to within a calculated centroid of 2.5 mm (several times higher resolution than legacy systems). You do this with an infrared light array. So, what do you do with those data? Well, you can of course calculate the time which the mouse [...]

Published on July 3rd, 2012|Founder's Blog|

Measuring food uptake differentially

Let's say you need to measure the food uptake of an experimental animal, which of course could mean any creature, including you. For the sake of simplicity, imagine a mouse or a rat feeding intermittently from a food hopper. You'd think that all you needed to do was weigh the hopper periodically, such as at [...]

Published on July 3rd, 2012|Founder's Blog|

Data, data, data!

This shows a day's worth of data from a single mouse in graphic form, recorded by a Promethion-C system for a research study on which I'm collaborating. The time resolution of the data set is one second. Loads of additional data (such as XY position and so on) didn't make it into the graph but are [...]

Published on July 3rd, 2012|Founder's Blog|

Automated behavior analysis: The basics of EthoScan

When mice (or rats) are wandering around their Promethion system cages and simply being mice (or rats), they interact with the various sensors in their cages – the mass sensors attached to their food and water dispensers, their body mass sensor, their running wheel, and their X-Y open-field position sensor, for example. In the Promethion [...]

Published on June 29th, 2012|Founder's Blog|