The Promethion ESA provides the unique ability to detect subtle or significant signals in the experimental operating environment that may influence research quality or confound its analysis. You will be able to see and document possible triggers for anomalous animal or cellular behaviors that typically go unexplained, including intrusive disturbances, variations in temperature or barometric pressure, and the impact of sound or light level. Information captured is integrated and synchronized with Sable’s Promethion MetaScreen, CaloScreen or SableScreen data collection and analysis software applications, allowing researchers to correlate environmental changes with study data. It can be teamed with any Promethion system for use in mouse and rat metabolic phenotyping, room calorimetry, genomics, metabolomics, cellular metabolism studies and more.
The Promethion Core Behavior Phenotyping System features the modular flexibility to support real-time behavioral studies in a home-cage setting. Capture a complete data-rich archive of behaviors with unbeatable temporal resolution. Second-by-second observations can discern seemingly subtle mouse behaviors relevant to your investigations that would otherwise be missed by less precise systems.
The Promethion Core High Definition Multiplexed Respirometry System for mice synchronously measures energy expenditure, RQ, VO2, VCO2 and activity. The SableHD™ High Definition platform updates once per second for all sensors in every cage – including position, food and water intake, wheel running, body mass and more – creating a richer data stream, secure GLP compliant raw data storage and analytical flexibility. Actual study data is preserved in its original form, ensuring full traceability for GLP compliance or peer review. This multiplexed system allows for the fastest sampling rates in the industry.
The Sable field version FlowKit is a integrated low-noise pump and mass flow generator housed in a portable, virtually indestructible carry case. It’s designed to accurately and quietly deliver large flow rates for applications such as large animal respirometry, or air circulation in small, controlled environments. Available in 3 different models – the FK-100-1, FK-500-1 and FK-2K-1 – for flow ranges of 5-100, 50-500, or 400-2000 liters per minute. The FlowKit relies on modulating a powerful but quiet pump in order to create the set mass flow rate. Ultra-efficient PID (proportional integral derivative) control is used for quick response to setpoint changes and minimal variation from the setpoint. As a result, the pump works only as hard as it has to, greatly reducing pump wear, power consumption and noise. A sub-sampling pump simplifies plumbing to a respirometry system, and features both analog and serial outputs for easy connection to a data acquisition system. The FlowKit requires no temperature or barometric pressure correction because it generates mass or molar flow rates already corrected to STP. It also features a user-configurable alarm to alert users locally and remotely if a fault develops. The FlowKit is powered from 24 VDC (universal adapter supplied) and can be operated from an optional battery pack for field use.
The Foxbox is a field portable combined oxygen and carbon dioxide analysis instrument including a variable pump and mass flow meter integrated into a compact, dustproof, waterproof case. Equally at home in the lab or the field, the Foxbox is the core of a complete respirometry system.