Acute Chamber

Short duration metabolic phenotyping research

Acute Chamber

Short duration metabolic phenotyping research

Features        Description       Specs        Downloads       Contact Us       Sable Enables

Features      Description     Specs      Downloads     Contact Us     Sable Enables

Features

  • Compact design for precision metabolic measurement
  • Optimized for multiple applications: optogenetic, therapeutic intervention, and physical stimuli
  • Adaptable for very small mammals
  • Short experiment turnaround time
  • Rapid experiments
  • Integrates with Promethion Core and Sable Classic Line systems

DESCRIPTION

The Acute Chamber is ideal for short-term experiments, typically lasting 1-4 hours.  This compact, low-volume chamber offers optimal conditions for capturing rapid and immediate changes in metabolism, often caused by various interventions.  The minimalist design, cannula aperture, and rapid response to changes make it perfect for studying tethered mice used in optogenetic or chemo-genetic studies or any study requiring a cannula such as blood sampling or glucose clamp procedures.  

It is also a perfect fit for very small mammals, such as shrews, or for dams with litters of young mice, where accurate metabolic measurement at low flow rates (under 2LPM) is critical.  Unlike traditional mouse cage lids, which are not designed for these lower flow rates, the acute chamber supports these specialized needs.

With its smaller volume – half the size of a standard mouse cage – it provides increased sensitivity and accuracy, making it a valuable tool for cutting-edge metabolic research. Up to 16 chambers can be connected to our Promethion Core system for high throughput analysis of short-term studies. The chamber can be rapidly cleaned for a fast turnaround time enabling multiples runs in a single day. 

The graph below shows rapid measurement of 13CO2 in response to infusion of 13-C labeled glucose tracer in an insulin clamp experiment. Data from Vanderbilt MMPC, MMPC@vanderbilt.edu.

 

View map of Promethion Core and Promethion Room Calorimetry academic installations

specs

Time Constant 1.25 minutes
Volume 2.5 Liter
Dimensions H: 19.5cm, W: 19.2 cm
Weight 2.1 lbs (0.95kg)
Multiplex Dwell Time (if in use with Promethion Core CGF) 15 seconds to continuous, dependent on how accurate the measures need to be
Flow Rate Recommendation 2 LPM
Max Flow Rate 3 LPM
Min Flow Rate 1.5 LPM

downloads

Download Product Note

contact us

Please fill out the form here and our specialists will help configure the right system for your needs or provide you with a detailed quote.

To request manuals and software updates, or find warranty and service information, please contact our Support department.