Description
Promethion uses pull-mode air flow generators, allowing the use of an unsealed “Home” cage environment for your animal. Cage activity and monitoring functions, including running wheel, food hopper, water bottle and scale, are built into the cage lid. You simply lift the lid to clean the cage, leaving the animal in the security of its home cage. There is no handling of the mouse, no unfamiliar new environment. This is a significant advancement over conventional systems sealed cage systems, which can cause stress effects and require long acclimation times.
Mouse Cage with Wheel and Accessories
The standard configuration model Mouse Cage comes with 2 cage tubs, cage lid with 3 accessory holes, air flow manifold with filters and tubing, an acrylic block and filter cover. Optional items include food/water hopper, body mass bracket and running wheel.
Pathogen Free Isolation Cage
We can equip the Tecniplast Isocage with running wheel, food intake, water intake and body mass sensors without compromising system integrity. This cage can even be used for nonmetabolic studies in the Tecniplast Isocage rack. It is also compatible with the BXYZ Total Activity Monitor.
Behavioral Mouse Cage
For acclimation or behavior-only studies, our cages can be fitted with perforated lids that allow generous air circulation without requiring active ventilation. All sensors can still be used if necessary.
Total Activity Monitoring
The BXYZ Beambreak Activity Monitor enables real time analysis of total activity with a 0.25cm calculated centroid. Designed to be modular, the BXYZ can easily be used stand alone, or synchronized with metabolic measurement and other elements of the Promethion system. It is capable of ignoring fixed objects, allowing flexibility to use standard or customized cages without interfering with activity monitoring. Using Sable data analysis software, you’ll have graphic representation of position within the cage, calculation of total distance traveled, rearing information, and storage of raw position vs. time data for other traceable, quantifiable analyses of activity level. The BXYZ is available in two versions – BXYZ-M for the mouse cage, and BXYZ-R for the rat cage. For labs using both mouse and rat cages, the larger BXYZ-R can be used interchangeably for either application.
ADX-Promethion
The ADX-Promethion is an activity detector that rest underneath a cage and records a range of vibrations (shivering to running) and translates that into an index of activity. The ADX will determine and measure the timing and magnitude of movement of small animals ranging from large insects to squirrels. Differential sensors are used for vibration detection and the product is designed to reduce external vibration, e.g. from an air conditioning unit or nearby footsteps. No calibration or adjustment is required to obtain excellent results. The ADX come in mouse and rat cage sizes.
ADX activity measurement correlates almost perfectly with “gold standard” infrared beam-break data (> 99%) and can be an alternative to the Promethion beambreaks, although both can be used simultaneously.
Wheel Activity Monitoring
The Promethion wheel monitoring system incorporates a durable, stainless steel wheel into the cage for 180 or 360 degree monitoring of voluntary wheel revolutions. Designed to integrate with calorimetry, the wheel monitoring data can easily be synchronized with RQ, VO2, beambreak activity, or any other parameter of the Promethion system.
The in-cage enrichment wheel provided with the Promethion wheel monitoring system is designed not to restrict flow around the wheel ensuring the most accurate and repeatable calorimetry data. The system provides superior temporal resolution with real time monitoring of revolutions per minute, permitting energy expenditure during running and resting periods to be easily differentiated.
Made of stainless steel, the wheel is autoclavable allowing the animal care facility to use existing cleaning and sterilizing systems reducing maintenance time and providing higher throughput for your system.
MM-2 Load Cell
The MM-2 load cell is a critical part of your Promethion food, water or body mass monitoring system. It provide 0.002 g resolution for the highest quality, most reliable results.
The Promethion universal MM-2 Load Cell can be used with any Promethion mass measurement device allowing the customization of the enrichment device and flexibility of the location of the device within the cage. Customization ensures compatibility of the body mass monitor with different animal behaviors or animal strains such as OB/OB mice and rats, providing unmatched flexibility in experimental design.
Recording of body mass can be combined with food and water intake, and synchronized with metabolic measurement, giving the investigator access to a more complete picture of energy expenditure.
Body Mass Monitoring
Promethion body mass monitors are in-cage enrichment devices attached to a Promethion universal MM-2 load cell. The body mass monitor allows the real time recording of body mass when the animal interacts with the device.
The real time data from the Promethion body mass monitor provides automated, voluntary weighing of the animal – up to 800 mg – resulting in frequent measurements of body mass and no handling stress on the animal during weighing.
Food Intake Monitoring
The Promethion food intake monitoring system features high precision sensors capable of measuring real time food intake for mice and rats. The MM-2 Load Cell with 3mg resolution can be used with the food hopper or any other Promethion mass measurement device, allowing maximum flexibility in feeding such as varying the location of the hopper within the cage and feeding liquid diets. The AC-2 Access Control Module can be setup for paired feeding, yoked feeding, time and duration limited feeding, and quantity limited feeding providing unmatched flexibility in experimental design.
The food hopper is made of stainless steel and autoclavable, allowing the animal care facility to use existing cleaning and sterilizing systems reducing maintenance time and providing higher throughput for your system. The built-in crumb catcher tray eliminates spilling and reduces caching behavior, providing more accurate and repeatable results from food intake analysis. With up to 750 grams of food storage, the real time monitoring of food intake may be used for 30 days or more without interruption or re-filling.
The Promethion food intake monitoring system can be incorporated into existing cage systems allowing the use of standard cages and requiring no cage modifications reducing animal stress during acclimation. Customizable lids are available for a variety of standard cage types.
Water Intake Monitoring
The Promethion water intake monitoring system includes a standard water bottle and a universal MM-2 Load Cell with a 3mg resolution. The MM-2 load cell can be used with many different water bottle sizes and shapes allowing the use of existing cleaning, sterilizing and filling supplies. The AC-2 Access Control Module allows controlled access to liquid diets or water consumption.
The system provides real time monitoring, allowing for drip mitigation that differentiates between drinking bouts and dripping events. Promethion also provides air flow through the cage keeping bedding dry leading to healthier, happier animals. With up to 500mL of water capacity, the water intake monitor may be used uninterrupted for up to 2 weeks without refilling.
The Promethion water intake monitoring system can be incorporated into existing cage systems allowing the use of standard cages and requiring no cage modifications reducing animal stress during acclimation. Customizable lids are available for a variety of standard cage types.
AC-2 Access Control
The AC-2 Access Control module is programmable to be open or closed by time of day or for paired or yoked studies.
CC-2 Cage Controller
The CC-2 Cage Controller attaches to each home cage to connect cage components to the Promethion data collection and analysis system.
