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Home/Products/Promethion Core Line/Promethion Core Cages and Monitoring
Promethion Core Cages and MonitoringJeff Richardson2020-10-27T11:02:23-07:00
Promethion Core Cages and Monitoring

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promethion-core-bz1
Fully Configured Multiplexed Respirometry Cage for Mice
Pathogen-Free-Isolation-Cage-with-Beam-Breaks
Fully configured pathogen-free isolation cage for mice with beam breaks

Features

  • Pull-mode air flow eliminates need for sealed cage
  • All cage functions are built into the lid, making it easy to change the cage bottom
  • Animal can stay in home cage, minimizing stress and acclimation time
  • Precision MM-2 mass monitoring unit, with 3mg resolution and up to 1000g capacity
  • Magnetic mounts for food and water for improved workflow efficiency

Description

Promethion uses pull-mode air flow generators, allowing the use of an unsealed “Home” cage environment for your animal. Cage activity and monitoring functions, including running wheel, food hopper, water bottle and scale, are built into the cage lid. You simply lift the lid to clean the cage, leaving the animal in the security of its home cage. There is no handling of the mouse, no unfamiliar new environment. This is a significant advancement over conventional systems sealed cage systems, which can cause stress effects and require long acclimation times.

Mouse Cage with Wheel and Accessories

The standard configuration model Mouse Cage comes with 2 cage tubs, cage lid with 3 accessory holes, air flow manifold with filters and tubing, an acrylic block and filter cover.  Optional items include food/water hopper, body mass bracket and running wheel.

Pathogen Free Isolation Cage

We can equip the Tecniplast Isocage with running wheel, food intake, water intake and body mass sensors without compromising system integrity. This cage can even be used for nonmetabolic studies in the Tecniplast Isocage rack.  It is also compatible with the BXYZ Total Activity Monitor.

Learn More

Behavioral Mouse Cage

For acclimation or behavior-only studies, our cages can be fitted with perforated lids that allow generous air circulation without requiring active ventilation. All sensors can still be used if necessary.

Total Activity Monitoring

The BXYZ Beambreak Activity Monitor enables real time analysis of total activity with a 0.25cm calculated centroid. Designed to be modular, the BXYZ can easily be used stand alone, or synchronized with metabolic measurement and other elements of the Promethion system.  It is capable of ignoring fixed objects, allowing flexibility to use standard or customized cages without interfering with activity monitoring.  Using Sable data analysis software, you’ll have graphic representation of position within the cage, calculation of total distance traveled, rearing information, and storage of raw position vs. time data for other traceable, quantifiable analyses of activity level.  The BXYZ is available in two versions – BXYZ-M for the mouse cage, and BXYZ-R for the rat cage. For labs using both mouse and rat cages, the larger BXYZ-R can be used interchangeably for either application.

Position probability heatmap

ADX-Promethion

The ADX-Promethion is an activity detector that rest underneath a cage and records a range of vibrations (shivering to running) and translates that into an index of activity. The ADX will determine and measure the timing and magnitude of movement of small animals ranging from large insects to squirrels.  Differential sensors are used for vibration detection and the product is designed to reduce external vibration, e.g. from an air conditioning unit or nearby footsteps.  No calibration or adjustment is required to obtain excellent results.  The ADX come in mouse and rat cage sizes.

ADX activity measurement correlates almost perfectly with “gold standard” infrared beam-break data (> 99%) and can be an alternative to the Promethion beambreaks, although both can be used simultaneously.

Wheel Activity Monitoring

The Promethion wheel monitoring system incorporates a durable, stainless steel wheel into the cage for 180 or 360 degree monitoring of voluntary wheel revolutions. Designed to integrate with calorimetry, the wheel monitoring data can easily be synchronized with RQ, VO2, beambreak activity, or any other parameter of the Promethion system.

The in-cage enrichment wheel provided with the Promethion wheel monitoring system is designed not to restrict flow around the wheel ensuring the most accurate and repeatable calorimetry data. The system provides superior temporal resolution with real time monitoring of revolutions per minute, permitting energy expenditure during running and resting periods to be easily differentiated.

Made of stainless steel, the wheel is autoclavable allowing the animal care facility to use existing cleaning and sterilizing systems reducing maintenance time and providing higher throughput for your system.

Running wheel activity monitoring

MM-2 Load Cell

The MM-2 load cell is a critical part of your Promethion food, water or body mass monitoring system.  It provide 0.002 g resolution for the highest quality, most reliable results.

The Promethion universal MM-2 Load Cell can be used with any Promethion mass measurement device allowing the customization of the enrichment device and flexibility of the location of the device within the cage. Customization ensures compatibility of the body mass monitor with different animal behaviors or animal strains such as OB/OB mice and rats, providing unmatched flexibility in experimental design.

Recording of body mass can be combined with food and water intake, and synchronized with metabolic measurement, giving the investigator access to a more complete picture of energy expenditure.

Body Mass Monitoring

Promethion body mass monitors are in-cage enrichment devices attached to a Promethion universal MM-2 load cell. The body mass monitor allows the real time recording of body mass when the animal interacts with the device.

The real time data from the Promethion body mass monitor provides automated, voluntary weighing of the animal – up to 800 mg – resulting in frequent measurements of body mass and no handling stress on the animal during weighing.

Food Intake Monitoring

The Promethion food intake monitoring system features high precision sensors capable of measuring real time food intake for mice and rats. The MM-2 Load Cell with 3mg resolution can be used with the food hopper or any other Promethion mass measurement device, allowing maximum flexibility in feeding such as varying the location of the hopper within the cage and feeding liquid diets.  The AC-2 Access Control Module can be setup for paired feeding, yoked feeding, time and duration limited feeding, and quantity limited feeding providing unmatched flexibility in experimental design.

The food hopper is made of stainless steel and autoclavable, allowing the animal care facility to use existing cleaning and sterilizing systems reducing maintenance time and providing higher throughput for your system.  The built-in crumb catcher tray eliminates spilling and reduces caching behavior, providing more accurate and repeatable results from food intake analysis. With up to 750 grams of food storage, the real time monitoring of food intake may be used for 30 days or more without interruption or re-filling.

The Promethion food intake monitoring system can be incorporated into existing cage systems allowing the use of standard cages and requiring no cage modifications reducing animal stress during acclimation. Customizable lids are available for a variety of standard cage types.

Food intake monitoring

Water Intake Monitoring

The Promethion water intake monitoring system includes a standard water bottle and a universal MM-2 Load Cell with a 3mg resolution. The MM-2 load cell can be used with many different water bottle sizes and shapes allowing the use of existing cleaning, sterilizing and filling supplies.  The AC-2 Access Control Module allows controlled access to liquid diets or water consumption.

The system provides real time monitoring, allowing for drip mitigation that differentiates between drinking bouts and dripping events. Promethion also provides air flow through the cage keeping bedding dry leading to healthier, happier animals.  With up to 500mL of water capacity, the water intake monitor may be used uninterrupted for up to 2 weeks without refilling.

The Promethion water intake monitoring system can be incorporated into existing cage systems allowing the use of standard cages and requiring no cage modifications reducing animal stress during acclimation. Customizable lids are available for a variety of standard cage types.

AC-2 Access Control

The AC-2 Access Control module is programmable to be open or closed by time of day or for paired or yoked studies.

CC-2 Cage Controller

The CC-2 Cage Controller attaches to each home cage to connect cage components to the Promethion data collection and analysis system.

Contact Us

For a custom configuration, contact us and our specialists will help you configure the right system for your specific research needs.

Downloads

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Specifications

3721 Mouse Cage

Tub Specifications
  • Material:
High-Temp Polysulfone (BPA free; autoclave up to 131 deg C)
  • Floor Area:
82 in2 (530 cm2)
  • Dimensions (W x D x H):
8.1 x 14.4 x 5.5 in. (21 x 37 x 14 cm)
  • Weight:
1.3 lb (0.6 kg)
Lid Specifications
  • Material:
Stainless Steel (autoclave up to 134 deg C)
  • Lid Types:
Solid, Wire, Vented
  • Accessory Mounting:
3 (mounting brackets included)
Accessories
Food Container  
  • Volume:
26 in3 (426 cm3)
  • Hopper Material:
Stainless Steel (autoclave up to 134 deg C)
Water Container  
  • Bottle Volume:
125 ml
  • Bottle Material:
Polyethylene (autoclave up to 120 deg C)
  • Hopper Material:
Stainless Steel (autoclave up to 134 deg C)
  • Sipper Material:
Stainless Steel (autoclave up to 134 deg C)
Enrichment Tube
  • Inner Diameter:
2 in. (5.1 cm)
  • Length:
4 in. (10.2 cm)
  • Tube Material:
Acrylic
  • Bracket Material:
Stainless steel
Options
  • Filter Cover:
Included
  • Material:
Polysulfone
  • Respirometer Manifold:
Included with Solid and Wire lids
  • Material:
Stainless Steel (autoclave up to 134 deg C)
Running Wheel
  • Diameter:
4.5 in.
  • Wheel counting:
Reed switch included (requires CC-1 cage controller)
  • Material:
Stainless Steel
Cage Floor
  • Material:
Stainless Steel mesh
AC-2 Food Access Control
  • Material:
Stainless Steel
  • Activation:
Servo motor (requires MM-1 mass monitor)
Overall Dimensions: 8.6 x 15.1 x 9 in. (21.8 x 38.4 x 22.9 cm) with lid and cover

AC-2 Access Control Module

Access Control Door
  • Position Precision:
10 deg
  • Movement Speed:
30 deg/sec
RGB LED
  • Color Range:
Over 16 Million colors
  • Maximum Red Intensity:
420 mcd
  • Maximum Green Intensity:
720 mcd
  • Maximum Blue Intensity:
200 mcd
  • Light Intensity Levels:
256
Communications: Sable CAN protocol via TRRS cable
Material: Stainless Steel Construction
Dimensions (W x D x H)
  • Mouse:
3.1 x 1.9 x 4.8 in (7.8 x 4.8 x 12.1 cm)
  • Rat:
3.1 x 1.9 x 6.8 in (7.8 x 4.8 x 17.3 cm)
Weight: 0.4 lbs (180 g)

BXYZ-M Mouse Beambreak

Location Measurement  
  • Position Resolution:
Physical Beam Spacing 1 cm
  • Effective Resolution:
0.25 cm
  • Scan Rate:
450 Hz
  • Beams in X Dimension:
20
  • Beams in Y Dimension:
36
Rearing Measurement  
  • Position Resolution:
Physical Beam Spacing 1 cm
  • Scan Rate:
450 Hz
  • Number of Beams:
36
  • Height Adjustment:
2.5 to 11.7 cm
Environmental Requirements  
  • Temperature:
5 deg C – 45 deg C
  • Relative Humidity:
10% to 90% non-condensing
Digital Interface: SableBus CAN Protocol, direct digital data transfer
Power Requirements: 12 – 24 VDC (Provided by SableBus)
Dimensions: 11.5 x 17.5 x 6 in (29.2 x 44.5 x 15.2 cm)
Weight: 7.5 lbs (3.4 kg)

ADX-Promethion & ADX-Reader

ADX-Promethion
Dimensions (W x D x H): Mouse: 8.35 x 13.4 x .75 in (21.2 x 34.0 x 1.9 cm)
Rat: 10.6 x 18.6 x .75 in (27.0 x 47.3 x 1.9 cm)
Weight: Mouse:  2.2 lbs (990g)
Rat: 3.7 lbs (1694 g)
Readable Weight: 0.033 – 4.4 lbs (15g – 2kg)
Communications: Analog out 0-5v
Operating Temperature: 0 – 50 C
Power Requirements: 110-220 VAC
ADX-Reader
Dimensions (W x D x H): 6.7 x 6.7 x 2.25 in. (17 x 17 x 5.7 cm)
Weight: 1.6 lbs (720g)
Channels: Expansion Modules available in 8 channel increments
Communications: SableBus via Mini-DIN used by Sable Classic instruments
SableCAN proprietary protocol used by Promethion instruments
Operating Temperature: 0 – 50 C
Power Requirements: 110-220 VAC

CC-2 Cage Controller

Digital Interface  
  • 2x SableBus Interface:
CAN Protocol; direct digital data transfer (main data bus)
  • 4x Device Interface:
CAN Protocol; direct digital data transfer (cage data bus, daisy-chainable 1 – 50 sensors)
Additional Inputs: Wheel rotation counter (reed switch input)
Power Requirements: 12 – 24VDC (data); universal adapter supplied
Dimension (W x D x H): 3.25 x 2.63 D x 1.3 in. (8.3 x 6.7 x 3.3 cm)
Weight: 0.2 lbs. (0.12 kg)

MM-2 Load Cell

Rated Load: 1 Kg
Resolution: 0.002 g RMS at 2 sec digital filtration
Sensor Type: Quad strain gauge
Data Precision: 24 bits (better than 1 part in 500,000)
Operating Temperature Range: -20 to +60 deg C
Non-Linearity: 0.015 % of rated output
Hysteresis: 0.008 % of rated output
Drift (over 2 minutes): <0.01 % of rated output
Digital Interface: SableBus; CAN Protocol, direct digital data transfer
Power Requirements: 5V (Provided by SableBus)

ADX promethion side by side
promethion-core-bz1
Fully Configured Multiplexed Respirometry Cage for Mice
promethion-mm2
promethion-core-body-mass-monitoring
promethion-core-water-intake-monitoring
promethion-core-wheel-activity-monitoring
promethion-core-pathogen-free-isolation-cage
promethion-core-Mouse-Cage-wheel-accessories
AC-2
CC-2
promethion-mouse-cage-food-intake-angle2

Promethion Core Line

Menu   ≡ ╳
  • Promethion Core Overview
  • Systems
    • Metabolic System, Mouse
    • Behavioral System, Mouse
    • GRID System, Rat
  • Cages and Monitoring
    • Cages (Standard and ISO)
    • Total Activity (ADX, XYZ beam break)
    • Wheel Activity
    • Food and Water
    • Body Mass
    • Mouse Respirometry Treadmill
  • Data Acquisition and Analysis
    • Promethion Core Software
  • Flow Generators and Gas Analyzers
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  • Environmental Control and Monitoring
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Sable Enables…

Most Trustworthy Results – Exclusive SableHD™ high definition digital technology provides industry-leading accuracy, highest sampling rate, and unbeatable resolution of rapidly changing metabolic data. And you get the full benefits of Promethion technology, including preservation of raw data, water vapor compensation, pull mode indirect calorimetry and home cage advantage.

Fewer Animals – High resolution analyzers and innovative multiplexing design give Promethion Core™ the ability to reduce experimental variability thereby reducing the number of animals needed per study and optimizing statistical power.

Ultimate Processing Power – Multiple Promethion Core™ 16-cage systems can be networked together for unmatched parallel processing power and highest reproducibility, enabling you to run multiple studies simultaneously or one large study on the same equipment.

Browser Based Data Management – Real-time animal data can be securely accessed via authorized desktop or mobile devices, including tablets and smart phones.

Ease of Maintenance – Innovative design enables technicians to efficiently manage animals, maintain the cages and clean the system.

What’s New

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    October 24, 2020
  • Inside Scientific Webinar: From Pregnancy to Menopause – Studies of Physical Activity, Behavior, and Energy Balance in Mice

    Inside Scientific Webinar: From Pregnancy to Menopause – Studies of Physical Activity, Behavior, and Energy Balance in Mice

    October 5, 2020
  • Promethion® Isocage Negative Pressure Mouse Cage

    Promethion® Isocage Negative Pressure Mouse Cage

    September 11, 2020
  • Inside Scientific Obesity Webinar: Utilizing Stable Isotope Tracers in Preclinical Models of Obesity  Copy

    Inside Scientific Obesity Webinar: Utilizing Stable Isotope Tracers in Preclinical Models of Obesity Copy

    July 30, 2020

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