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Home/Products/Promethion Core Line/Promethion Core High-Definition Multiplexed Respirometry System for Mice
Promethion Core High-Definition Multiplexed Respirometry System for MiceJeff Richardson2020-02-11T06:56:27-08:00
Promethion Core High-Definition Multiplexed Respirometry System for Mice

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Updated-Promethion-Core-1-1000px
16-cage Promethion Core Rack
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Fully Configured Multiplexed Respirometry Cage for Mice
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Promethion Core Rack Mounted Instrumentation

Features

  • SableHD™ for highest resolution, sampling rate and accuracy
  • High-throughput and efficient workflow
  • Flexibility to run multiple studies simultaneously on one set of equipment
  • Secure browser-based access to real-time data and reports
  • Synchronization of metabolic data with activity, food and water uptake and body mass
  • Fastest cage time constant (full cage air exchange) and cycle time (multiplexed sampling rate every 2.5 minutes) for accurately recording fast metabolic events
  • Autocalibration process without chemical scrubbers
  • Battery backup in case of power outage
  • Easy maintenance and cleaning

Description

The Promethion Core High Definition Multiplexed Respirometry System for mice synchronously measures energy expenditure, RQ, VO2, VCO2 and activity.  The SableHD™ High Definition platform updates once per second for all sensors in every cage – including position, food and water intake, wheel running, body mass and more – creating a richer data stream, secure GLP compliant raw data storage and analytical flexibility.  Actual study data is preserved in its original form, ensuring full traceability for GLP compliance or peer review.  This multiplexed system allows for the fastest sampling rates in the industry.

Each Promethion Core™ rack system has its own analyzers and on-board computer for data acquisition and storage, providing optimized monitoring of up to 16 animals.  Multiple racks are easily networked together with all data combined into one large database, maximizing scalability of study size without compromising quality of results. Multiple studies can be configured and run simultaneously without adding computing equipment.  Researchers can monitor each animal 24/7 via a browser-based interface accessible by authorized smartphones, tablets or computers.  One-hour battery backup allows uninterrupted data acquisition during transport or during a power failure.  The system is designed for optimizing workflow efficiency, with hot-swappable components and magnetic mounts for quick exchange of hoppers and measurement devices.

This leading-edge system is designed by scientists, for scientists, to provide optimal animal enrichment without sacrificing accuracy.  High resolution data is dependent on constant flow and rapid exchange of air in the cage.  Only Sable Systems guarantees complete air exchange of 15 times per hour in each cage in compliance with IACUC standards for mouse calorimetry.  In contrast, poorly circulating airflow caused by the add-on gantries or other push-mode limitations of conventional systems creates error prone ‘dead space.’  Improper air flow and slow cage air exchange leads to blurring of the metabolic data making it impossible to clearly distinguish active and resting periods, compromising the accuracy of the metabolic data overall.

Key Components*

  • Promethion Core Rack Mount Instrumentation includes:
    • Triple Gas Single Path Analyzer
    • 16-channel Flow Generator and Multiplexer
    • Promethion IM-3 Interface Module including onboard computer and memory
  • Vacuum Pump
  • Precision Mass Monitors
  • Magnetic Mount Food Hopper
  • Magnetic Mount Water Bottle with Sipper Tube
  • Data Acquisition and Analysis Software
  • Browser-based interface accessible by authorized smartphones, tablets or computers on the lab’s intranet.
  • 1-hr Battery backup

Optional Components*

  • Body Mass Measurement – Enrichment Accessory
  • Access Control Unit
  • 3-D IR Beam Break Array
  • Activity Detector Vibration Sensor Pad
  • Desktop Computer with Monitor
  • Telemetry Bases for Temperature, Heart Rate and Activity
  • Running Wheel
  • Environmental Sensor Array
  • Pathogen-Free Isolation Mouse Cage

Contact Us

For a custom configuration, contact us and our specialists will help you configure the right system for your specific research needs.

Downloads

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Promethion Core Rack Mounted Instrumentation

Promethion Core Line

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  • Promethion Core Overview
  • Systems
    • Metabolic System, Mouse
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  • Cages and Monitoring
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    • Total Activity (ADX, XYZ beam break)
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    • Food and Water
    • Body Mass
    • Mouse Respirometry Treadmill
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    • Promethion Core Software
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  • Environmental Control and Monitoring
    • CAB-8 and CAB-16 Environmental Control Cabinets
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Sable Enables…

Most Trustworthy Results – Exclusive SableHD™ high definition digital technology provides industry-leading accuracy, highest sampling rate, and unbeatable resolution of rapidly changing metabolic data. And you get the full benefits of Promethion technology, including preservation of raw data, water vapor compensation, pull mode indirect calorimetry and home cage advantage.

Fewer Animals – High resolution analyzers and innovative multiplexing design give Promethion Core™ the ability to reduce experimental variability thereby reducing the number of animals needed per study and optimizing statistical power.

Ultimate Processing Power – Multiple Promethion Core™ 16-cage systems can be networked together for unmatched parallel processing power and highest reproducibility, enabling you to run multiple studies simultaneously or one large study on the same equipment.

Browser Based Data Management – Real-time animal data can be securely accessed via authorized desktop or mobile devices, including tablets and smart phones.

Ease of Maintenance – Innovative design enables technicians to efficiently manage animals, maintain the cages and clean the system.

What’s New

  • Inside Scientific Webinar – Comfort Food: Effects of Stress and High-Fat Diets on Neuronal Activity and Mitochondrial Remodeling in Mice

    Inside Scientific Webinar – Comfort Food: Effects of Stress and High-Fat Diets on Neuronal Activity and Mitochondrial Remodeling in Mice

    February 5, 2021
  • Inside Scientific Webinar: Sex, Sugar, Fat, and Heat: Factors That Affect Energy Budgets, Weight Management and Behaviors in Mice

    Inside Scientific Webinar: Sex, Sugar, Fat, and Heat: Factors That Affect Energy Budgets, Weight Management and Behaviors in Mice

    October 24, 2020
  • Inside Scientific Webinar: From Pregnancy to Menopause – Studies of Physical Activity, Behavior, and Energy Balance in Mice

    Inside Scientific Webinar: From Pregnancy to Menopause – Studies of Physical Activity, Behavior, and Energy Balance in Mice

    October 5, 2020
  • Promethion® Isocage Negative Pressure Mouse Cage

    Promethion® Isocage Negative Pressure Mouse Cage

    September 11, 2020

UPCOMING EVENTS

Mar
9
Tue
1:00 pm Comfort Food: Effects of Stress ... @ Inside Scientific Webinar
Comfort Food: Effects of Stress ... @ Inside Scientific Webinar
Mar 9 @ 1:00 pm – 2:00 pm
 
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