Promethion Core Temperature Measurement System
Real-time remote monitoring of mouse body temperature
Promethion Core Temperature Measurement System
Real-time remote monitoring of mouse body temperature
Features
- Small-sized microchip and easy implantation reduces mouse stress and shortens recovery time
- Body temperature data can be acquired from mouse activities, such as activity in the mouse wheel and movement or rest along the cage floor
- Fully integrated and optimized with Promethion Core hardware and software
- Can be added to existing Promethion Core systems in the field
- High resolution temperature readings, with 0.1˚C accuracy
- Large temperature measurement range
- High data acquisition rate for synchronization with metabolic and behavioral data
- Microchip is injectable subcutaneously or intraperitoneally
DESCRIPTION
The Promethion Core Temperature Measurement System (TMS) enables you to monitor body temperature in animals during experiments, providing a less stressful way to track temperature changes. You can acquire body temperature during normal mouse activities, such as running in the mouse wheel and movement or rest along the cage floor.
This integrated system consists of a tiny, temperature sensing microchip, a microchip injector, an under-cage mounted antenna for communication with the mouse implanted microchip, a multiplexed reader for cage switching and data handling (see photos), and a handheld reader for quick temperature scans.
Teamed with a Promethion Core metabolic and behavioral phenotyping system, the TMS delivers mouse temperature readings from each cage into the Promethion Live software platform. You’ll have the ultimate solution for understanding behavioral and physiological changes in individual animals over time.
TMS experiment setup is simple and practical. The microchip injector is used to insert the sterile microchip either subcutaneously or intraperitoneally (core temperature), enabling temperature measurement at different body sites. For precise placement, such as next to the liver, the microchip may be surgically implanted. The small size of the microchip and easier implantation reduces mouse stress compared to traditional implants, providing quicker recovery time. Post-implantation, functionality is verified by measurement with the handheld reader.
Implanted mice are then individually housed in Promethion Core cages integrated with TMS. This provides hands free temperature measurements for the duration of each study, enabling the synchronization of accurate (±0.1°C @ 38°C in increments of 0.1°C) temperature changes with changes in mouse metabolism and behavior. The TMS temperature data is integrated with the Promethion Core metabolic and behavioral phenotyping data, completing the routine setup and mouse temperature measurement within Promethion Core.
Solving the Problems of Mouse Temp Measurement
Traditional temperature measurement methods present challenges for routine use. Many temperature sensors require surgical implantation at a single site, delivering only core body temperature. The surgery and sensor size cause animal stress, lengthy recovery time, and delayed experiments. Rectal thermometry, the most common method for core temperature assessment, is time consuming, labor intensive, and induces significant animal distress due to the required manual restraint. While non-contact infrared thermometry is less invasive, it provides surface temperature only and is highly inaccurate.
The TMS’s use of small, injectable temperature-sensing microchips offers an innovative solution to these problems.
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