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Home/Products/Promethion Line/Promethion High-Definition Behavioral Phenotyping System for Rats
Promethion High-Definition Behavioral Phenotyping System for RatsJeff Richardson2019-06-18T20:26:43-07:00
Promethion High-Definition Behavioral Phenotyping System for Rats

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product-classic-Rat-Behavior-System
Promethion High-Definition Behavioral Phenotyping System for Rats
product-classic-resp-rat-wheel-3
Promethion High-Definition Continuous Respirometry Cage with Wheel for Rats
promethion-rat-cage-w-acc-fl_angle
Promethion High-Definition Multiplexed Respirometry Cage for Rats

Features

  • High-resolution, synchronized, multiplexed behavioral phenotyping system for rats
  • Enables capture and analysis of a wide range of rat behaviors
  • Small scale or high-throughput and workflow friendly
  • Feeding options include paired or yoked, time and duration, food choice or behavior-based reward
  • Time budgets, e.g., distance traveled, non-ambulatory budgets
  • Wheel running and/or activity restriction
  • Behavioral transition ethogram analysis

Description

The Promethion line features the modular flexibility to support real-time behavioral studies in a home-cage setting with a small sample size or large-scale neurophysiological, pharmacokinetic and toxicological studies. Our high-definition behavioral phenotyping system for rats combines beam-break activity measurement with continuous input from all in-cage devices to capture a data-rich archive of activity with unbeatable temporal resolution.  Second-by-second observations can discern seemingly subtle rat behaviors relevant to your investigations that would otherwise be missed by less precise systems.  Select a stand-alone system or add Promethion metabolic measurement functions at a later date.

The Promethion Ethoscan behavioral phenotyping package is a built-in application within Sable’s Expedata software that analyzes the interaction of the animal with in-cage devices such as the food hopper, water bottle and enrichment devices.  Combined with wheel running and non-wheel ambulatory budgets a behavioral transition matrix can be created for profiling individuals or cohorts. High definition resolution combined with a deep data field offer statistical powers.  Also our digital systems are fully compatible with video tracking analysis systems from leading scientific manufacturers. Sable also gives you the flexibility advantage:  gas analyzers, flow generators, multiplexers, software and interfaces can be used interchangeably for rat or mouse by adding the appropriate activity detector.

Key Components*

  • Cage System with Additional Home Cage
  • Cage Controller
  • Mass Measurement Device
  • Food Hopper
  • Water Hopper
  • Body Mass and Cage Enrichment Device
  • Promethion Interface Module
  • Data Acquisition and Analysis Software
  • Data Acquisition Software for Multiplexed Promethion Systems

Optional Components*

  • Access Control Unit
  • 3-D IR Beam Break Array
  • Desktop Computer with Monitor
  • Temperature Control Cabinet (Solid or Clear Door)
  • Environmental Monitoring Device
  • Heavy Duty Wire Shelf
  • Telemetry Bases for Temperature and Activity
  • Telemetry Bases for Temperature, Heart Rate and Activity
  • Activity Wheel

*Quantity of individual components will vary, depending upon your sample size and/or number of cages.

Promethion's resolution enables the capture of even "micro" events, such as micro feeding events

In the graphs above, we show intake events over a 24-hour period by 8 C57BL/6J mice using logarithmic axes (error bars are 1 SE). The Promethion System’s ability to detect micro intake events is demonstrated by the point cloud extending into the lower left portion of the graph. These micro events constitute 30-40% of feeding events, however, they cannot be detected by conventional systems.

Graph of body mass, energy expenditure, and activity

Promethion’s high resolution activity detection arrays capture actual activity and discard noise, giving an accurate indication of real activity (orange trace at the bottom of the graph). Body mass is shown as the black line at the top of the graph and energy expenditure (EE) is in blue. You can see that the EE drops to a low, relatively stable level when the mouse (in this case a 22 g C57BL/6J male) is inactive. The small oscillations visible in EE during inactivity are real, and are not detectable by lower-resolution systems. Then, with each bout of activity, you can see EE rising to a relatively stable level and falling back down to resting levels after the activity bout ceases. Due to Promethion’s high resolution, there is no blurring or smearing of the data.

Contact Us

For a custom configuration, contact us and our specialists will help you configure the right system for your specific research needs.

Downloads

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Promethion High-Definition Multiplexed Respirometry Cage for Rats

Promethion Line

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  • Promethion Overview
  • Systems
    • Human Room Calorimetry
    • Behavioral Phenotyping, Mouse
    • Behavioral Phenotyping, Rat
    • Large Animal
    • Multiplexed Respirometry, Mouse
    • Multiplexed Respirometry, Rat
  • Cages & Monitoring
    • Cages
    • Total Activity
    • Wheel Activity
    • Food & Water
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  • Interfaces
    • ACI-12 Interface
    • IM3 Interface Module
  • Environmental Control and Monitoring
    • CAB-8 and CAB-16 Environmental Control Cabinets
    • ESA Environmental Sensor Array
  • Accessories
    • CER Integrated Relay

Sable Enables…

High Definition Analysis – Exclusive SableHD™ high definition digital technology provides industry-leading accuracy, highest sampling rate, and unbeatable resolution of rapidly changing metabolic data.

Integration and Expandability – Fully-integrated Promethion systems optimize overall performance, provide turn-key operation, and allow expandability as your needs change.

Preservation of Raw Data – Your actual study data is preserved in its original form with up to 1-second resolution, ensuring full traceability for GLP compliance or peer review. Other systems untraceably alter then discard your raw data, preventing study validation or re-analysis.

Water Vapor Compensation – Sable indirect calorimetry systems measure water vapor dilution directly, eliminating sample gas drying and significantly increasing accuracy.

Pull-Mode Indirect Calorimetry – Secures greater accuracy and animal safety. Without a sealed cage prone to deteriorating seals, errors caused by “push-mode” leaks are eliminated. Your animal is in a low-stress environment, safeguarded in the event of a power failure.

Home Cage Advantage – Minimizes stress effects and their attendant metabolic/biochemical artifacts.

What’s New

  • Inside Scientific Webinar: Sex, Sugar, Fat, and Heat: Factors That Affect Energy Budgets, Weight Management and Behaviors in Mice

    Inside Scientific Webinar: Sex, Sugar, Fat, and Heat: Factors That Affect Energy Budgets, Weight Management and Behaviors in Mice

    October 24, 2020
  • Inside Scientific Webinar: From Pregnancy to Menopause – Studies of Physical Activity, Behavior, and Energy Balance in Mice

    Inside Scientific Webinar: From Pregnancy to Menopause – Studies of Physical Activity, Behavior, and Energy Balance in Mice

    October 5, 2020
  • Promethion® Isocage Negative Pressure Mouse Cage

    Promethion® Isocage Negative Pressure Mouse Cage

    September 11, 2020
  • Inside Scientific Obesity Webinar: Utilizing Stable Isotope Tracers in Preclinical Models of Obesity  Copy

    Inside Scientific Obesity Webinar: Utilizing Stable Isotope Tracers in Preclinical Models of Obesity Copy

    July 30, 2020

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