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- Sable Systems Announces New Sable Regenerative Policy
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- Professor Shingo Kajimura presented with the 2024 Sable Award
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- Professor Kathryn E. Wellen presented with The Sable Award in Metabolic Physiology
- John Lighton, PhD – How he founded Sable Systems and revolutionized the measurement of metabolism
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Publications
- Maternal High-Fat Diet-Induced Obesity in Offspring: Unraveling Adipose Tissue Dysfunction Mediated by Increased Heat Shock Proteins. Paz HA. et al Elsevier. 9/1/2025.
- Guide for the Care and Use of Laboratory Animals. . .
- Diabetes. . .
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- B-Hydroxy-B-methylbutyrate (HMB) increases muscle mass and diminishes weight gain in high-fat-fed mice. Cohen-Or M. et al Elsevier. 8/1/2025.
- ATF4 Deletion in Brown Adipocytes Attenuates Diet-Induced Insulin Resistance in Male Mice Independently of Weight Gain. Marti A. et al Endocrinology. 8/1/2025.
- microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism. Ismaeel A. et al Molecular Metabolism. 8/1/2025.
- Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice Yin, Wen; Xu, Heng; Bai, Zhonghao; Wu …. Zhang C. et al Nature Communications. 7/21/2025.
- Angiotensin AT1R Expressing Cells Within the Ventral Hypothalamus Modulate Integrative Control of Cardiometabolic Functions. Pasos J. et al Cell. 7/18/2025.
- Adipose tissue protein kinase D (PKD): regulation of signalling networks and its sex-dependent effects on metabolism. Renton MC. et al Physiology. 6/25/2025.
- 2178-LB: BI-4659, an Adipose Tissue–Enriched Mitochondrial Uncoupler, Reverses Diet-Induced Obesity in Mice. PEREIRA M. et al Diabetes. 6/20/2025.
- Smurf Mice: revolutionising our understanding of age-related and end-of-life animal physiology. Cansell C. et al bioRxiv. 6/19/2025.
- A bioenergetic basis for multiorgan dysfunction in sepsis. Jentho E. et al bioRxiv. 6/17/2025.
- In C57Bl6 Mice, Obesity and Subsequent Weight Loss Negatively Affected the Skeleton and Shifted the Cortical Bone Metabolome. Chlebek C. et al bioRxiv. 6/13/2025.
- An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis. Zhang Y. et al Cell. 6/11/2025.
- A repeatedly evolved mutation in Cryptochrome-1 of subterranean animals alters behavioral and molecular circadian rhythms. Swaminathan A. et al Cell. 6/11/2025.
- Topical application of the cold-mimetic l-menthol decreases wheel running without affecting the beneficial effects of voluntary exercise in mice. Bellucci A. et al The Physiological Society. 6/11/2025.
- Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects. DeLeon O. et al Cell. 6/6/2025.
- Haptoglobin and Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy. Campelj DG. et al Journal of Cachexia, Sarcopenia and Muscle. 6/5/2025.
- Endoplasmic reticulum Nogo drives AgRP neuronal activation and feeding behavior. Jin S. et al Cell. 6/3/2025.
- Elevated IGFBP4 and Cognitive Impairment in a PTFE-Induced Mouse Model of Obstructive Sleep Apnea. Al Madhoun A. et al preprints.org. 6/3/2025.
- Hyperinsulinemia-induced upregulation of adipocyte TPH2 contributes to peripheral serotonin production, metabolic dysfunction, and obesity. Park BI. et al The Journal of Clinical Investigation. 6/2/2025.
- Hepatic glycogen directly regulates gluconeogenesis through an AMPK/CRTC2 axis in mice. Zhang B. et al The Journal of Clinical Investigation. 6/2/2025.
- Global deletion of COX-2 Attenuates Hepatic Inflammation but Impairs Metabolic Homeostasis in Diet-Induced Obesity. Balakrishnan J. et al Journal of Lipid Research. 6/1/2025.
- Acute NAD+ Supplementation via NMN Does Not Rescue Functional Impairment in a LPS-Induced Delirium Mouse Model. Chui MKK. et al Journal of Gerontology. 5/30/2025.
- Preoptic EP3R neurons constitute a two-way switch for fever and torpor. Machado NLS. et al Nature. 5/28/2025.
- The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot. Marinescu AM. et al bioRxiv. 5/28/2025.
- BRCA1 influences whole body metabolism in humanized mice. Hembruff S. et al Physiology. 5/27/2025.
- The gut-brain axis mechanism of normal appetite induced by kynurenic acid. Pan L. et al Cell. 5/27/2025.
- Maternal obesity programs cardiac remodeling in offspring via epigenetic, metabolic, and immune dysregulations. Philips EA. et al bioRxiv. 5/27/2025.
- Metabolic Cage Analysis of Surgically Catheterized C57Bl/6J Mice (Mus musculus) Treated with Carprofen and Sustained-release Buprenorphine. Tu J. et al bioRxiv. 5/26/2025.
- Multi-Omics and -Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset. Xu LL. et al Wiley Online Library. 5/24/2025.
- The Mitochondrial Brown Adipose Tissue Maintenance Factor Nipsnap1 Interfaces Directly with the Beta-Oxidation Protein Machinery in Rodents.. Tsai PY. et al Elsevier. 5/23/2025.
- Reutericyclin mitigates risperidone-induced suppression of anaerobic energy expenditure. Hadiono MA. et al Physiology. 5/22/2025.
- Semaglutide effects on energy balance are mediated by Adcyap1+ neurons in the dorsal vagal complex. Teixidor-Deulofeu J. et al Cell Metabolism. 5/22/2025.
- AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway. Su A. et al Cell & Bioscience. 5/22/2025.
- Validating a novel capability of assessing pathways of animal water gain and loss. Steele ZT. et al Royal Society Publishing. 5/21/2025.
- Gallic acid prevents obesity in mice on a high-fat diet via the gut microbiota-adipose tissue axis. Jian S. et al Elsevier. 5/20/2025.
- A murine model of Barth syndrome recapitulates human cardiac and skeletal muscle phenotypes. Yazawa E. et al Disease Models & Mechanisms. 5/19/2025.
- Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice. Bruner KR. et al bioRxiv. 5/17/2025.
- Postnatal hyperosmolality alters development of hypothalamic feeding circuits with context-specific changes in ingestive behavior. Sweet SR. et al Cell. 5/16/2025.
- Edible cannabinoids impact meal structure and food impulsivity in female rats. Lord MN. et al Cell. 5/16/2025.
- AgRP neuron hyperactivity drives hyperglycemia in a mouse model of type 2 diabetes. Gou Y. et al The Journal of Clinical Investigation. 5/15/2025.
- Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3. Kotikalapudi N. et al Nature. 5/13/2025.
- Modulation of liver lipid metabolic pathways by central nervous system ER stress. Kim HR. et al American Journal of Physiology. 5/13/2025.
- Ubiquitous expression of an activating mutation in the Pik3ca gene reprograms glucose and lipid metabolism in mice. Caiazzo S. et al PLOS. 5/12/2025.
- YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARγ. Wang L. et al EMBO press. 5/12/2025.
- Vulnerability of the gastric mucosa to the ulcerogenic action of indomethacin and energy metabolism in KK. CG-Ay/J, KK. CG-a/J and C57BL/6J mice. Filaretova L. et al Physiology. 5/12/2025.
- Integrative metabolic profiling of hypothalamus and skeletal muscle in a mouse model of cancer cachexia. Choi JY. et al Elsevier. 5/12/2025.
- Arduino allows development of a low-cost, high-resolution metabolic and behavioral phenotyping system for birds. Rogers EJ. et al Journal of Experimental Biology. 5/9/2025.
- The metabolically protective energy expenditure increase of Pik3r1-related insulin resistance is not explained by Ucp1-mediated thermogenesis. Luijten I. et al American Journal of Physiology. 5/9/2025.
- Ceramide-induced FGF13 impairs systemic metabolic health. Naderi J. et al Cell Metabolism. 5/6/2025.
- KHK in leptin receptor-expressing neurons is dispensable for fructose preference and energy homeostasis. Yu Z. et al Elsevier. 5/1/2025.
- Enhanced metabolic adaptations following late dark phase wheel running in high-fat diet-fed mice. Ashcroft SP. et al Elsevier. 5/1/2025.
- High-Protein Diet Prevents Glucocorticoid-Induced Fat Mass Accumulation and Hyperglycemia. Burke SJ. et al MDPI. 5/1/2025.
- Adenosine A2A Receptors Link Astrocytic α1-Adrenergic Signaling to Wake-Promoting Dopamine Neurons. Petersen N. et al Elsevier. 5/1/2025.
- Adipocyte Septin-7 attenuates obesogenic adipogenesis and promotes lipolysis to prevent obesity. Xu L. et al Elsevier. 5/1/2025.
- Therapeutic Effects of Different Ultrasound Intensity Stimulation on Brown Adipose Tissue for the Treatment of Type 2 Diabetes. Bat-Erdene B. et al Elsevier. 5/1/2025.
- NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging. Chubanava S. et al Cell. 4/30/2025.
- Cholinergic neuron circadian clock mediates RNA-binding protein function and contributes to ALS disease phenotypes. Tam SB. et al bioRxiv. 4/29/2025.
- Separating anorexia-dependent and-independent effects in cancer cachexia. Liang Y. et al bioRxiv. 4/26/2025.
- FGF21 signals through KLB-expressing glutamatergic neurons in the hindbrain to mediate the effects of dietary protein restriction. Spann RA. et al bioRxiv. 4/24/2025.
- Cold memories control whole-body thermoregulatory responses. Muñoz Zamora A. et al Nature. 4/23/2025.
- Prolactin modulation of thermoregulatory circuits provides resilience to thermal challenge of pregnancy. Ladyman SR. et al Cell. 4/22/2025.
- Synthesis and Pharmacological Characterization of Novel Peripheral Cannabinoid-1 Receptor Blockers Based on a Tricyclic Scaffold. Gammal A. et al Journal of Medicinal Chemistry. 4/21/2025.
- Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice. Wu D. et al Cell Biology. 4/17/2025.
- GDF15 links adipose tissue lipolysis with anxiety. Townsend LK. et al Nature. 4/15/2025.
- Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations. Rampy J. et al bioRxiv. 4/15/2025.
- α2-Adrenergic Receptors in Hypothalamic Dopaminergic Neurons: Impact on Food Intake and Energy Expenditure. Park BS. et al International Journal of Molecular Sciences. 4/9/2025.
- Single-nucleus mRNA-sequencing reveals dynamics of lipogenic and thermogenic adipocyte populations in murine brown adipose tissue in response to cold. Behrens J. et al bioRxiv. 4/5/2025.
- The SnackerTracker: A novel home-cage monitoring device for measuring food-intake and food-seeking behaviour in mice. Mueller M. et al Wellcome Open Research. 4/4/2025.
- The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT. Bunk J. et al Nature. 4/4/2025.
- The impact of oral cannabis consumption during pregnancy on maternal spiral artery remodelling, fetal growth and offspring behaviour in mice. Ritchie TM. et al The Lancet. 4/1/2025.
- Time-Resolved Effects of Short-term Overfeeding on Energy Balance in Mice. Ranea-Robles P. et al Diabetes. 4/1/2025.
- Hepatic HKDC1 deletion alleviates western diet-induced MASH in mice. Xu K. et al Elsevier. 4/1/2025.
- Vertical sleeve gastrectomy and semaglutide have distinct effects on skeletal health and heart function in obese male mice. Picoli CC. et al American Journal of Physiology. 4/1/2025.
- An organism-level quantitative flux model of energy metabolism in mice. Yuan B. et al Cell Metabolism. 4/1/2025.
- HEXA-FC protein therapy increases skeletal muscle glucose uptake and improves glycaemic control in mice with insulin resistance and in a mouse model of …. Montgomery MK. et al Springer. 3/29/2025.
- APOE4 Exerts Partial Diet-dependent Effects on Energy Expenditure and Skeletal Muscle Mitochondrial Pathways in a Preclinical Model. Johnson CN. et al Function. 3/25/2025.
- Food insecurity promotes adiposity in mice. Gil CRE. et al Obesity. 3/23/2025.
- Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity. Chang YC. et al EMBO press. 3/21/2025.
- Sex differences in metabolic regulation by Gi/o-coupled receptor modulation of exocytosis. Young M. et al Frontiers. 3/18/2025.
- Effects of Multivitamin Supplementation on Metabolic Parameters in High-and Low-Fat Diet-Fed C57BL/6J Mice: Potential Links to Adipose Tissue Browning. Abbasi M. et al MDPI. 3/17/2025.
- Comprehensive microarray analysis for the identification of therapeutic targets within HIF-1α signalling networks in diet-induced obesity via hypothalamic …. Guo H. et al Archives of Endocrinology and Metabolism. 3/14/2025.
- Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance. Hägele FA. et al Nature Metabolism. 3/13/2025.
- Fat taste responsiveness, but not dietary fat intake, is affected in Adipor 1 null mice. Lin F. et al bioRxiv. 3/13/2025.
- Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle. Bond ST. et al Nature. 3/8/2025.
- Skeletal muscle mitochondrial dysfunction is associated with increased Gdf15 expression and circulating GDF15 levels in aged mice. Chen J. et al Nature. 3/8/2025.
- MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue. Zhao XY. et al Wiley Online Library. 3/7/2025.
- A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan. Jayne L. et al Nature. 3/7/2025.
- Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut. Zhang Y. et al Cell. 3/4/2025.
- Lactate homeostasis is maintained through regulation of glycolysis and lipolysis. Lee WD. et al Cell. 3/4/2025.
- RBM43 controls PGC1α translation and a PGC1α-STING signaling axis. Dumesic PA. et al Cell. 3/4/2025.
- Pregnancy and a high‚Äêfat, high‚Äêsugar diet each attenuate mechanosensitivity of murine gastric vagal afferents, with no additive effects. Clarke GS. et al The Journal of Physiology. 3/2/2025.
- P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function. Munoz M. et al Springer. 3/2/2025.
- Housing temperature influences metabolic phenotype of heart failure with preserved ejection fraction in J vs N strain C57BL/6 mice. Chaudhary R. et al Elsevier. 3/1/2025.
- Sucrase isomaltase dysfunction reduces sucrose intake in mice and humans. Aldiss P. et al Elsevier. 3/1/2025.
- Monocyte control of organismal energy homeostasis. Martins R. et al bioRxiv. 2/27/2025.
- Long-lasting recombinant HEXA improves hepatic steatosis and glycemic control in mild, but not severe, metabolic dysfunction-associated steatohepatitis. Lin S. et al American Physiology Society. 2/25/2025.
- Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis. Nguyen PTT. et al Cell. 2/25/2025.
- Deoxycholic acid ameliorates obesity and insulin resistance by enhancing lipolysis and thermogenesis. Tuerhongjiang G. et al Springer Nature. 2/25/2025.
- Sensing of Long-Chain Fatty Acyl-CoA Esters by AMPK. Desjardins EM. et al Nutrient Sensing in Eukaryotes. 2/25/2025.
- Autophagy suppresses CCL2 to preserve appetite and prevent lethal cachexia. Ibrahim M. et al bioRxiv. 2/24/2025.
- Adenosine Monophosphate Improves Lipolysis in Obese Mice by Reducing DNA Methylation via ADORA2A Activation by Ecto‐5′‐Nucleotidase (CD73). Cui Z. et al Wiley Online Library. 2/20/2025.
- Male mouse skeletal muscle lacking HuR shows enhanced glucose disposal at a young age. Noland RC. et al Frontiers. 2/19/2025.
- Modeling metabolic disease susceptibility and resilience in genetically diverse mice. Baker CN. et al bioRxiv. 2/16/2025.
- Peroxisomal Dysfunction Drives Loss of Dynamic Nutrient Responses to Initiate Metabolic Inflexibility During Aging. Sharma A. et al bioRxiv. 2/16/2025.
- Lrtm1-A Novel Sensor of Insulin Signaling and Regulator of Metabolism and Activity. Yu Y. et al Diabetes Journal. 2/7/2025.
- Cold-induced thermogenesis requires neutral-lipase-mediated intracellular lipolysis in brown adipocytes. Mouisel E. et al Cell Metabolism. 2/4/2025.
- Pancreatic expression of CPT1A is essential for whole body glucose homeostasis by supporting glucose-stimulated insulin secretion. Ducote MP. et al Journal of Biological Chemistry. 2/1/2025.
- Leptin receptor neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss. Francois M. et al Elsevier. 2/1/2025.
- Diet-induced obesity mediated through Estrogen-Related Receptor α is independent of intestinal function. Vemuri K. et al Journal of Biological Chemistry. 2/1/2025.
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- Activation of Muscular TrkB by its Small Molecular Agonist 7,8-Dihydroxyflavone Sex-Dependently Regulates Energy Metabolism in Diet-Induced Obese Mice. Bun Chan C, Chui Ling Tse M, Liu X, Zhang S, Schmidt R, Otten R, Liu L, Ye K. Chemistry & Biology. 3/19/2015.
- Leptin Signaling Is Required for Adaptive Changes in Food Intake, but Not Energy Expenditure, in Response to Different Thermal Conditions. Kalyala KJ, Ogimoto K, Nelson JT, Schwartz MW, Morton GJ. PLOS ONE. 3/10/2015.
- Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction. Vieira-Potter VJ, Padilla J, Park YM, Welly RJ, Scroggins RJ, Britton SL, Koch LG, Jenkins NT, Crissey JM, Zidon T, Morris EM, Meers GME, Thyfault JP. American Journal of Physiology. 1/21/2015.
- Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity. Chen Z, Guo L, Zhang Y, Walzem RL, Pendergast JS, Printz RL, Morris LC, Matafonova E, Stien X, Kang L, Coulon D, McGuinness OP, Niswender KD, Davies SS. The Journal of Clinical Investigation. 8/1/2014.
- FGF-21 and Skeletal Remodeling During and After Lactation in C57BL/6J Mice. Bornstein S, Brown SA, Le PT, Wang X, DeMambro V, Horowitz MC, MacDougald O, Baron R, Lotinum S, Karsenty G, Wei W, Ferron M, Kovacs CS, Clemmons D, Wan Y, Rosen CJ. Endocrinology. 6/30/2014.
- Matrix Metalloproteinase 9 Opposes Diet-Induced Muscle Insulin Resistance in Mice. Kang L, Hayes WH, James FD, Bracy DP, Wasserman DH. Diabetologia. 3/1/2014.
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