The common fruit-fly, Drosophila melanogaster, holds promise for enhanced understanding of highly conserved disease pathways shared by both flies and humans. Use of such an insect model is a cost effective opportunity for therapeutic discovery that includes central nervous system disorders, inflammatory disorders, cardiovascular disease, cancer, and diabetes. Calorimetry, or small insect respirometry can be an effective tool in drug screens, replacing or enhancing in-vitro, small molecule research.
Salient Features
- Measurement and control of atmospheric gas concentrations including water vapor
- Metabolic measurement
Sable Solutions
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Promethion High-Definition Room Calorimetry System
Promethion High-Definition Behavioral Phenotyping System for Mice
Promethion High-Definition Behavioral Phenotyping System for Rats
Promethion High-Definition Continuous Respirometry System for Mice
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Relevant Publications
Ma, J., Benson, A. K., Kachman, S. D., Jacobsen, D. J., & Harshman, L. G. (2013). Drosophila melanogaster Selection for Survival after Infection with Bacillus cereus Spores: Evolutionary Genetic and Phenotypic Investigations of Respiration and Movement. International journal of evolutionary biology, 2013.
Ridley, E. V., Wong, A. C., Westmiller, S., & Douglas, A. E. (2012). Impact of the resident microbiota on the nutritional phenotype of Drosophila melanogaster. PLoS One, 7(5), e36765.
Avanesian, A., Khodayari, B., Felgner, J. S., & Jafari, M. (2010). Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster. Biogerontology, 11(1), 45-52.