Insects as Models of Disease

The common fruit-fly, Drosophila melanogaster, holds promise for enhanced understanding of highly conserved disease pathways shared by both flies and humans. Use of such an insect model is a cost effective opportunity for therapeutic discovery that includes central nervous system disorders, inflammatory disorders, cardiovascular disease, cancer, and diabetes. Calorimetry, or small insect respirometry can be an effective tool in drug screens, replacing or enhancing in-vitro, small molecule research.

Home

Biomedicine Physiology Environmental Progress in science is driven by scientists. The tools life scientists use, however, are frequently designed by people whose foundations are from outside the lab; people who lack a ... Read More

Promethion High-Definition Room Calorimetry System

The Promethion High-Definition Room Calorimetry System is capable of synchronously recording all measured parameters in a completely traceable manner. Key components of this system include the GA-3m2 triple gas O2, CO2, and ... Read More

Promethion High-Definition Behavioral Phenotyping System for Mice

The Promethion line features the modular flexibility to support real-time behavioral studies in a home-cage setting with a small sample size or large-scale neurophysiological, pharmacokinetic and toxicological studies. Our high-definition behavioral phenotyping ... Read More

Promethion High-Definition Behavioral Phenotyping System for Rats

Promethion High-Definition Continuous Respirometry System for Mice

When high temporal resolution is critical, so is the selection of a “continuous” system for indirect calorimetry measurements. Similar to the Promethion multiplexed systems, this high-definition continuous system for mice combines ultra-high ... Read More

Our systems are highly customizable for a broad range of applications. Let us help configure a system to meet your specific research needs.

Help Me Configure a System

Salutation:
First Name
Last Name
Company
Email
City
Country:
Region:
Notes:

Relevant Publications

Ma, J., Benson, A. K., Kachman, S. D., Jacobsen, D. J., & Harshman, L. G. (2013). Drosophila melanogaster Selection for Survival after Infection with Bacillus cereus Spores: Evolutionary Genetic and Phenotypic Investigations of Respiration and Movement. International journal of evolutionary biology, 2013.

Ridley, E. V., Wong, A. C., Westmiller, S., & Douglas, A. E. (2012). Impact of the resident microbiota on the nutritional phenotype of Drosophila melanogaster. PLoS One, 7(5), e36765.

Avanesian, A., Khodayari, B., Felgner, J. S., & Jafari, M. (2010). Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster. Biogerontology, 11(1), 45-52.