Thermal measurement and control of an experimental environment is required whenever temperatures must be known and stabilized or where the change of temperature must be regulated. Thermal-limit respirometry* is an innovative method measuring metabolic response as an indicator of optimal performance, thermal tolerance, thermal stress or critical limits.
Thermal physiology spans diverse disciplines. Ecologists can establish the physiological criteria for species distribution. Hypothermic and hyperthermic consequences are of interest in comparative physiology and also in biomedical studies of obesity and diabetes (see Founders White Paper). And tissue regeneration or drug efficacy can be indicated thermally and therapeutic countermeasures to inflammation or burn treatment can be evaluated.
Salient Features
- Temperature measurement and control
- Integrate with high-resolution calorimetry
- Set setpoint to continuous value
- Step the setpoint using variable soak times
- Ramp and maintain at a setpoint, single shot or repeat ramps
- Integrate with controlled atmospheric instrumentation
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Relevant Publications
Comparative and Evolutionary Physiology:
Jensen, P., Overgaard, J., Loeschcke, V., Schou, M. F., Malte, H., & Kristensen, T. N. (2014). Inbreeding effects on standard metabolic rate investigated at cold, benign and hot temperatures in< i> Drosophila melanogaster</i>. Journal of insect physiology, 62, 11-20.
**Lighton, J. R., & Turner, R. J. (2004). Thermolimit respirometry: an objective assessment of critical thermal maxima in two sympatric desert harvester ants, Pogonomyrmex rugosus and P. californicus. Journal of Experimental Biology, 207(11), 1903-1913.
Nguyen, C., Bahar, M. H., Baker, G., & Andrew, N. R. (2014). Thermal Tolerance Limits of Diamondback Moth in Ramping and Plunging Assays. PloS one, 9(1), e87535.
**Mölich, A. B., Förster, T. D., & Lighton, J. R. (2012). Hyperthermic overdrive: oxygen delivery does not limit thermal tolerance in Drosophila melanogaster. Journal of Insect Science, 12.
Schilthuizen, M., & Kellermann, V. (2014). Contemporary climate change and terrestrial invertebrates: evolutionary versus plastic changes. Evolutionary Applications, 7(1), 56-67.
Zub, K., Fletcher, Q. E., Szafrańska, P. A., & Konarzewski, M. (2013). Male weasels decrease activity and energy expenditure in response to high ambient temperatures. PloS one, 8(8), e72646.
Biomedical Phenotyping or Exercise Physiology Applications:
Gosselin, C., & Haman, F. (2013). Effects of green tea extracts on non-shivering thermogenesis during mild cold exposure in young men. British Journal of Nutrition, 110(02), 282-288.
Pearson, J., Kalsi, K. K., Stöhr, E. J., Low, D. A., Barker, H., Ali, L., & González-Alonso, J. (2013). Haemodynamic responses to dehydration in the resting and exercising human leg. European journal of applied physiology, 113(6), 1499-1509.
Metzler‐Wilson, K., Sammons, D. L., Ossim, M. A., Metzger, N. R., Jurovcik, A. J., Krause, B. A., & Wilson, T. E. (2014). Extracellular calcium chelation and attenuation of calcium entry decrease in vivo cholinergic‐induced eccrine sweating sensitivity in humans. Experimental physiology, 99(2), 393-402.
Gosselin, C., & Haman, F. (2013). Effects of green tea extracts on non-shivering thermogenesis during mild cold exposure in young men. British Journal of Nutrition, 110(02), 282-288.
Trangmar, S. J., Chiesa, S. T., Stock, C. G., Kalsi, K. K., Secher, N. H., & González‐Alonso, J. (2014). Dehydration affects cerebral blood flow but not its metabolic rate for oxygen during maximal exercise in trained humans. The Journal of physiology.