Controlled Atmospheres: Hypoxia, Anoxia, Hypercapnic or Hyperoxic Research

Control and modulation of atmospheres can be utilized to understand the physical composition and behavior of materials or to investigate key evolutionary, ecological, physiological and biomedical questions.

A subset of applications includes Anoxic or hypoxic pre/ post-natal development, CO2 control in incubation, post- harvest storage, aerobic capacity of athletic performance, circadian rhythm and sleep studies, and adaptation to hypoxia in burrowing organisms. Cellular mechanisms are better understood from model animal investigations of the effect of O2 concentrations on reperfusion injury from stroke or trauma, reactive oxygen species regulation and the oxidative stress response.

Important System Considerations

Measure and Control O2, CO2, Water Vapor and Pressure

  • Set setpoint to continuous value
  • Ramp and maintain at a setpoint
  • Step the setpoint using variable soak times
  • Single shot or repeat ramps
  • Use with temperature control cabinetry
  • Module available for Pressure regulation

Sable SOlutions

Classic Line

Sable Classic line instruments provide the ultimate combination of performance and flexibility in in the measurement and control of gas, flow, humidity, temperature and pressure. We offer a broad range of devices that can be configured as a…
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Relevant Publications

Relevant Publications

Biomedical or Exercise Physiology

Lindgren, I., & Altimiras, J. (2013). Prenatal hypoxia programs changes in β-adrenergic signaling and postnatal cardiac contractile dysfunction. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 305(10), R1093-R1101.

Crocker, G. H., Toth, B., & Jones, J. H. (2013). Combined effects of inspired oxygen, carbon dioxide, and carbon monoxide on oxygen transport and aerobic capacity. Journal of Applied Physiology, 115(5), 643-652.

Kelly, S. A., Rezende, E. L., Chappell, M. A., Gomes, F. R., Kolb, E. M., Malisch, J. L., … & Garland, T. (2014). Exercise training effects on hypoxic and hypercapnic ventilatory responses in mice selected for increased voluntary wheel running. Experimental physiology, 99(2), 403-413.

Bavis, R. W., DeAngelis, K. J., Horowitz, T. C., Reedich, L. M., & March, R. J. (2014). Hyperoxia-induced developmental plasticity of the hypoxic ventilatory response in neonatal rats: Contributions of glutamate-dependent and PDGF-dependent mechanisms. Respiratory physiology & neurobiology, 191, 84-94. 

Evolutionary and Ecological Physiology:

Jew, C. J., Wegner, N. C., Yanagitsuru, Y., Tresguerres, M., & Graham, J. B. (2013). Atmospheric oxygen levels affect mudskipper terrestrial performance: implications for early tetrapods. Integrative and comparative biology, ict034.

Hawkes, L. A., Butler, P. J., Frappell, P. B., Meir, J. U., Milsom, W. K., Scott, G. R., & Bishop, C. M. (2014). Maximum Running Speed of Captive Bar-Headed Geese Is Unaffected by Severe Hypoxia. PloS one, 9(4), e94015.

Tiedke, J., Thiel, R., & Burmester, T. (2014). Molecular response of estuarine fish to hypoxia: A comparative study with ruffe and flounder from field and laboratory. PloS one, 9(3), e90778.

Environmental and Stored Products

Sousa, A. H., Faroni, L. R. D. A., & da Silva Freitas, R. (2014). RELATIVE TOXICITY OF MUSTARD ESSENTIAL OIL TO INSECT-PESTS OF STORED PRODUCTS. Revista Caatinga, 27(2), 222-226.

Magwaza, L. S., Opara, U. L., Cronje, P. J., Landahl, S., & Terry, L. A. (2013). Canopy position affects rind biochemical profile of ‘Nules Clementine’mandarin fruit during postharvest storage. Postharvest Biology and Technology, 86, 300-308.