DESCRIPTION

The Promethion Core Mouse Metabolic System gives you the truest and most trustworthy results from your mouse phenotyping studies. At the heart of the system is the highest resolution metabolic measurement instrumentation, yielding accurate resting and active energy expenditure values.

Second-by-second behavioral measurements provide the highest data granularity. Promethion Core tightly synchronizes all metabolic and behavioral data, allowing you to pinpoint and correlate metabolism changes with behavioral events. All the raw data is saved for further data mining.

Other systems try to match Promethion Core’s performance by employing an oversampling technique, for example, continuous gas measurements of each cage. But due to these systems’ low-resolution gas analyzers and requisite slow air-exchange rates, continuous oversampling simply results in useless and redundant data (see video “The Effects of Cage Air-Flow Rate”).

The system is expandable to enable microbiome research with our biocontainment cage plus methane analyzer, fuel utilization research with our stable isotope gas analyzer, and temperature/light-controlled studies with our Environmental Control Cabinet. You can even  connect 3rd party equipment such as telemetry and optogenetic systems.

The entire system is compact and self-contained to save valuable lab space, allowing up to 16 cages in an environmental cabinet. This provides 33% more housed cages than competitor systems, maximizing your experimental power. Your workflow is efficient with swappable components and magnetic mounts for quick exchange of hoppers and measurement devices.

The new Promethion Live software enables you to control all aspects of your study. The simplified interface maximizes experiment success with intuitive system and experiment setup. One-step gas calibration ensures accurate respirometry measurements. Status indicators for vital components verify system performance. Constant monitoring of all parameters means you will always know the well-being of each animal. Routine experiment configurations can be easily saved and reused.

With Promethion Live, you can explore comparative trends during an experiment looking at every parameter measured, such as running speed, food consumed, or energy expended (data shown). The software uniquely provides the mean (± SD; ± SEM) or median of grouped data for real-time statistical comparison and experiment evaluation. You’re empowered with the real-time experiment and animal information needed to make key decisions at any time, from any place.

Key Components

• Promethion Core instrumentation includes:
  • Triple gas single path analyzer
  • 8-channel flow generator and multiplexer
  • Promethion Live onboard computer and memory
• Standard size home cage
• Precision mass monitors
• Magnetic mount food hopper
• Magnetic mount water bottle with sipper tube
• 2- or 3-dimensional infrared beam break array
• Promethion Live software platform
• Desktop computer with monitor

Optional Components

• Body mass habitat
• Running wheel
• Access control door for food hopper or water bottle
• Environmental Sensor Array (ESA)
• Environmental control cabinet
• Telemetry bases for body temperature and heart rate
• Stable Isotope Analyzer (¹³CO₂)
• Methane Analyzer
• Optogenetic compatible cage lid

View map of Promethion Core and Promethion Room Calorimetry academic installations

specs

downloads

Promethion Core – brochure
Promethion Live Software – brochure
Environmental Control Cabinets – Product Note

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