The scale of life’s diversity –of its past and present forms and function, is arguably as fascinating as the challenges that confront the researcher compelled by curiosity to understand how organisms work. Eco-Evolutionary physiology and its subset, the study of organismal energetics and behavior in a changing environment, is one of the essential disciplines that integrates ecological, physiological, biomedical and pharmacokinetic research. Indirect calorimetry is one of its most important methods. The metrics of O2 consumption, CO2 emission, water vapor and energy flux provide the substantive accounting for good predictive modeling – whether that modeling more accurately describes the range of a keystone species, or the physiological trade-offs involved in aging or the efficacy of treatments for disease.

For further reference, see Grand Challenges of Organismal Biology.

Salient Features

  • Highest accuracy in measurement of metabolic rate from microbes to whales
  • Highest resolution O2 analysis
  • Highest range and stability of CO2 measurement
  • Direct measurement of water vapor pressure
  • Exceptional accuracy in calculation of RQ

Sable Solutions

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Promethion High-Definition Room Calorimetry System

The Promethion High-Definition Room Calorimetry System is capable of synchronously recording all measured parameters in a completely traceable manner. Key components of this system include the GA-3m2 triple gas O2, CO2, and ... Read More

Promethion High-Definition Behavioral Phenotyping System for Mice

The Promethion line features the modular flexibility to support real-time behavioral studies in a home-cage setting with a small sample size or large-scale neurophysiological, pharmacokinetic and toxicological studies. Our high-definition behavioral phenotyping ... Read More

Promethion High-Definition Behavioral Phenotyping System for Rats

The Promethion line features the modular flexibility to support real-time behavioral studies in a home-cage setting with a small sample size or large-scale neurophysiological, pharmacokinetic and toxicological studies. Our high-definition behavioral phenotyping ... Read More

Promethion High-Definition Continuous Respirometry System for Mice

When high temporal resolution is critical, so is the selection of a “continuous” system for indirect calorimetry measurements. Similar to the Promethion multiplexed systems, this high-definition continuous system for mice combines ultra-high ... Read More

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Relevant Publications

Careau, V., Hoye, B., O’Dwyer, T., & Buttemer, B. (2014). Among-and within-individual correlations between basal and maximal metabolic rates in birds. The Journal of experimental biology, jeb-108704.

Chen, C. C. W., & Welch, K. C. (2014). Hummingbirds can fuel expensive hovering flight completely with either exogenous glucose or fructose. Functional Ecology, 28(3), 589-600.

Dlugosz, E. M., Chappell, M. A., Meek, T. H., Szafrańska, P. A., Zub, K., Konarzewski, M., … & Garland, T. (2013). Phylogenetic analysis of mammalian maximal oxygen consumption during exercise. The Journal of experimental biology, 216(24), 4712-4721.

Jew, C. J., Wegner, N. C., Yanagitsuru, Y., Tresguerres, M., & Graham, J. B. (2013). Atmospheric oxygen levels affect mudskipper terrestrial performance: implications for early tetrapods. Integrative and comparative biology, ict034.

Ma, J., Benson, A. K., Kachman, S. D., Jacobsen, D. J., & Harshman, L. G. (2013). Drosophila melanogaster Selection for Survival after Infection with Bacillus cereus Spores: Evolutionary Genetic and Phenotypic Investigations of Respiration and Movement. International journal of evolutionary biology, 2013.

Maciak, S., Bonda‐Ostaszewska, E., Czarnołęski, M., Konarzewski, M., & Kozłowski, J. (2014). Mice divergently selected for high and low basal metabolic rates evolved different cell size and organ mass. Journal of evolutionary biology, 27(3), 478-487.

Wit, J., Sarup, P., Lupsa, N., Malte, H., Frydenberg, J., & Loeschcke, V. (2013). Longevity for free? Increased reproduction with limited trade-offs in Drosophila melanogaster selected for increased life span. Experimental gerontology, 48(3), 349-357.