Mouse Metabolic Treadmill

Fully automated treadmill for routine exercise studies

Mouse Metabolic Treadmill

Fully automated treadmill for routine exercise studies

Features        Description       Specs        Downloads       Contact Us       Sable Enables

Features      Description     Specs      Downloads     Contact Us     Sable Enables


  • Highest resolution gas analyzers (H2O, O2 and COstandard; 13CO2, and CH4 optional)
  • Automated self-leveling ensures incline accuracy
  • Mouse-activated auditory, blue light and shock stimuli as well as manual brush stimulus
  • Programmable incline, speed, and acceleration
  • Chamber design eliminates user air contamination
  • Optimized for metabolic measurement with no dead space
  • Includes several high contrast backgrounds to enhance video recording
  • Real-time experiment monitoring by Promethion Live software


Measuring the Metabolic Costs of Exercise

The Sable Metabolic Treadmill is an enclosed, single chamber treadmill designed specifically for the metabolic measurement of mice. The treadmill optimizes metabolic measurement with a wide range of settings for inclination, speed, and acceleration—including four options for stimulating the mouse to exercise. Integrated with the Promethion Core metabolic system and Promethion Live software, the treadmill provides real-time system monitoring and graphing of experimental data.

Mouse stimuli includes shock grid and LED lights, sound and manual push brush.

Flexible Design

The treadmill provides exceptional flexibility to choose how to design your experiment. You have fine control of speed, acceleration, and incline as well as wide adjustable ranges for each parameter. These parameters are changed via the treadmill controller box, eliminating the need to manually adjust the treadmill. Unique to the Sable Metabolic Treadmill design is automatic chamber leveling to ensure accurate incline and trusted results. Four stimulus choices are available, including electric shock, light, sound, and a manually-operated push brush. Clear chamber windows and insertable backgrounds for contrast enhancement optimize video recordings.

To clean the treadmill, simply lift the chamber off the treadmill for full access to the running belt. The running belt, chamber, and the two removable waste trays may be cleaned with routine animal husbandry cleaning products.

Incline adjustment from -20 to +40 degrees with black high contrast background.


The user can program and store up to fifteen unique exercise profiles, with each profile containing up to 45 individual changes in speed, inclination, and acceleration. The intensity and duration of the voltage, light, and sound stimuli are also programmable and can be set to run in combination or individually. These automated stimuli trigger when the mouse steps on the shock grid. Programming is performed with the treadmill controller box through a user-friendly touch screen interface via gloved hand, stylus or by loading preset templates. Animal metadata can be included in the datafiles for traceability.

Superior Metabolic Measurement

The treadmill uniquely synchronizes changes in a mouse’s metabolism (VO– rate of oxygen consumption, RER – respiratory exchange ratio, and EE – energy expenditure) in response to changes in speed and/or inclination. Pull-mode respirometry and optimal air flow design eliminates air-circulation artifacts generated by the moving belt. Care is taken to ensure the incurrent airstream is not altered by the researcher’s respiration. High air flow rate (3.5 liters per minute) and the superior performance of Promethion Core analyzers deliver the industry best metabolic measurement accuracy and resolution, allowing you to see what others miss.


The Mouse Respirometry Treadmill enables cardiorespiratory fitness tests analogous to human fitness tests. These include sub-maximal and maximal tests to assess VO2max. Tests may be single or multistage. Short test duration enables many tests to be completed per day. The high-performance gas analyzers resolve rapid respirometry changes to quantify the degree of change in response to changing speed or incline (including changes in fuel utilization). Semi-quantitative assessment of fuel utilization is determined by the respiratory exchange ratio.

Quantitative fuel utilization is possible when the Promethion Core metabolic system is coupled to our Stable Isotope Analyzer. This analyzer enables the quantitation of the catabolism of specific fuels (such as glucose, fructose, and palmitic acid) in addition to the standard respirometry measurements.

Real-time VCO2, VO2, EE, RER, Speed and Incline shown for a single mouse as recorded by a Promethion Core system connected to the Mouse Metabolic Treadmill.

Animal Safety

The treadmill is designed with animal safety as a priority. The shock grid is programmable and cannot exceed 5 mA current. Sable test runs used only 1 mA and required only one or two sessions to train naive animals to run with consistent rhythm. The sound and/or light stimulus provide the researcher notification when the mouse steps on the shock grid and the stabilized belt allows for an emergency stop with access to the experimental animal within 2 seconds.

Promethion Core®

Promethion Core® is the only metabolic and behavioral phenotyping system that enables you to tightly synchronize metabolic data with behavioral events. You will see every aspect of metabolism and behavior more clearly, with finer detail, quality, and repeatability—giving you complete confidence in your data.

Key Components

  • Promethion Core Instrumentation includes:
    • Triple Gas Single Path Analyzer
    • 8-channel Flow Generator and Multiplexer
    • Promethion Live onboard computer and memory
  • Metabolic treadmill
  • Treadmill Control Box
  • Promethion Live Software Platform
  • Desktop Computer with Monitor

View map of Promethion Core and Promethion Room Calorimetry academic installations


Programmable speed
0 to 100 m/min

Programmable incline
-20 to 40°

0-100 m/min2 in 0.1 m/min2 increments

Chamber volume
3.75 L

Air flow Rate for Metabolic Measurement
3.5 L/min

15 programmable run profiles, max 45 steps in each

Data recording
Internal: SD card
External: Promethion Live

Operating Temperature
4° to 45° Celsius

Full integration with Promethion Core metabolic phenotyping system

Manual stimulus
Push Brush

Stimulus settings
Shock, Light, Sound
Shock Grid: 0 to 5 mA adjustable in 0.1 mA increments;
duration: 5 to 500 milliseconds
Sound range: 70 to 85 dB and a frequency of 5kHz
Light range: 20 lux to 14000 lux at a wavelength of 450-475nm
blue light flash 

Treadmill dimensions
12.5” height x 19.1” width x 10.0” depth (31.75cm x 48.5cm x 25.4cm)

Treadmill weight
< 30 pounds (< 13.6kg)

Patent Pending


Sable Metablic Treadmill Product Note
VO2 max Application Note

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Please fill out the form here and our specialists will help configure the right system for your needs or provide you with a detailed quote.

To request manuals and software updates, or find warranty and service information, please contact our Support department.