APPLICATIONS

Obesity

The disease of obesity accounts for, directly or indirectly, reduced quality of life of affected individuals and imposes substantial societal economic costs. Obesity is not only an underpinning of major chronic diseases such as heart disease, cancer, stroke, and diabetes, to name a few, but can be a serious debilitating condition in its own right. Research into obesity comes from multiple disciplines ranging from clinical practice to translational research to molecular and cellular biology.

Obesity affects all physiological systems. Therefore, comprehensive metabolic and behavioral phenotyping is essential to understanding the complex origins of obesity and how to treat it.

Important System Considerations

Animal Research

Food and water intake with automated access control; paired or yoked feeding capacity
Activity monitoring in a home cage environment
Stress free body mass measurement in a home cage environment
Meal pattern analysis
Micro-event data acquisition for high-resolution analysis of ingestion and other behaviors
Metabolism measurement
Specific nutrient utilization measurement
Temperature regulation

Human Research

Human room calorimetry
Activity monitoring

Sable SOlutions

CAB-8 and CAB-16 Environmental Control Cabinets

The CAB-8 and CAB-16 provide environmental control for your Promethion Core rodent metabolism and behavioral system. These cabinets provide up to 100 user-defined changes in temperature and light intensity over the course of your study. Control and real…

Promethion Core Metabolic System, Mouse

The Promethion Core High Definition Multiplexed Respirometry System for mice synchronously measures energy expenditure, RQ, VO2, VCO2 and activity. The SableHD™ High Definition platform updates once per second for all sensors in every cage – including position, food…

Promethion Core Metabolic System, Rat

Promethion High-Definition Room Calorimetry System

The Promethion High-Definition Room Calorimetry System is capable of synchronously recording all measured parameters in a completely traceable manner. Key components of this system include the GA-3m2 triple gas O2, CO2, and H2O dual path analyzer with…

Stable Isotope Gas Analyzer

Continuous measurement of 13C and 18O isotopes in exhaled breath The new Stable Isotope Gas Analyzer is a cutting-edge upgrade to our standard Promethion™ systems, allowing simultaneous measurement of stable isotope tracers synchronously with the Promethion data stream…

Please fill out the form here and our specialists will help configure the right system for your needs or provide you with a detailed quote.

To request manuals and software updates, or find warranty and service information, please contact our Support department.

Relevant Publications

105 Results Found (Showing 1 - 6)

Butyrate mitigates metabolic dysfunctions via the ERα-AMPK pathway in muscle in OVX mice with diet-induced obesity. Fu Q, Li T, Zhang C, Ma X, Meng L, Liu L, Shao K, Wu G, Zhu X, & Zhao X. Cell Communication and Signaling. 5/4/2023.

May 4, 2023 12:00 am Published by Brett Davis

Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice. Yan S, Zhou X, Wu C, Gao Y, Qian Y, Hou J, Xie R, Han B, Chen Z, Wei S & Gao X. Nature Communications. 3/13/2023.

March 13, 2023 12:00 am Published by Brett Davis

Rhynchophylline relieves nonalcoholic fatty liver disease by activating lipase and increasing energy metabolism. Liu K, Liu S, Wu C, Wang Y, Zhang Y, Yu J, Liu S, Li X, Qi X, Su S, Qi X, Zhou L, & Li L. International Immunopharmacology. 3/11/2023.

March 11, 2023 12:00 am Published by Brett Davis

The combined effect of metformin and mirabegron on diet-induced obesity. Zhao X-Y, Liu Y, Zhang X, Zhao B-C, Burley G, Yang Z-C, Luo Y, Li A-Q, Zhang R-X, Liu Z-Y, Shi Y-C, & Wang Q-P. MedComm. 2/14/2023.

February 14, 2023 12:00 am Published by Brett Davis

The clock-modulatory activity of Nobiletin suppresses adipogenesis via Wnt signaling. Xiong X, Kiperman T, Li W, Dhawan S, Lee J, Vijay Y, & Ma K. bioRxiv. 2/8/2023.

February 8, 2023 12:00 am Published by Brett Davis

High-fat/high-sucrose diet worsens metabolic outcomes and widespread hypersensitivity following early-life stress exposure in female mice. Frick JM, Eller OC, Foright RM, Levasseur BM, Yang X, Wang R, Winter MK, O’Neil MF, Morris EM, Thyfault JP, & Christianson JA. American Physiological Society. 1/24/2023.

January 24, 2023 12:00 am Published by Brett Davis

APPLICATIONS

Obesity

CAB-8 and CAB-16 Environmental Control Cabinets

Promethion Core Metabolic System, Mouse

Promethion Core Metabolic System, Rat

Promethion High-Definition Room Calorimetry System

Stable Isotope Gas Analyzer

Relevant Publications

Publications Filter - Applications Page - Obesity

Butyrate mitigates metabolic dysfunctions via the ERα-AMPK pathway in muscle in OVX mice with diet-induced obesity. Fu Q, Li T, Zhang C, Ma X, Meng L, Liu L, Shao K, Wu G, Zhu X, & Zhao X. Cell Communication and Signaling. 5/4/2023.

Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice. Yan S, Zhou X, Wu C, Gao Y, Qian Y, Hou J, Xie R, Han B, Chen Z, Wei S & Gao X. Nature Communications. 3/13/2023.

Rhynchophylline relieves nonalcoholic fatty liver disease by activating lipase and increasing energy metabolism. Liu K, Liu S, Wu C, Wang Y, Zhang Y, Yu J, Liu S, Li X, Qi X, Su S, Qi X, Zhou L, & Li L. International Immunopharmacology. 3/11/2023.

The combined effect of metformin and mirabegron on diet-induced obesity. Zhao X-Y, Liu Y, Zhang X, Zhao B-C, Burley G, Yang Z-C, Luo Y, Li A-Q, Zhang R-X, Liu Z-Y, Shi Y-C, & Wang Q-P. MedComm. 2/14/2023.

The clock-modulatory activity of Nobiletin suppresses adipogenesis via Wnt signaling. Xiong X, Kiperman T, Li W, Dhawan S, Lee J, Vijay Y, & Ma K. bioRxiv. 2/8/2023.

Sable Enables

Sable Enables

Sable Enables

Helmholtz Diabetes Conference 2023

High-Resolution Metabolic and Behavioral Phenotyping Course

Chinese Association for Physiological Scienses