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Slide Obesity

Applications

Home/Applications/Biomedical Research/Obesity
ObesityBrett Davis2022-03-25T10:18:10-07:00

The disease of obesity accounts for, directly or indirectly, reduced quality of life of affected individuals and imposes substantial societal economic costs.  Obesity is not only an underpinning of major chronic diseases such as heart disease, cancer, stroke, and diabetes, to name a few, but can be a serious debilitating condition in its own right.  Research into obesity comes from multiple disciplines ranging from clinical practice to translational research to molecular and cellular biology.

Metabolic measurement is essential in much of the research to understand the cause of the energy imbalance that leads to increased adiposity and related chronic diseases.

Important System Considerations

Animal Research

  • Food and water intake with automated access control; paired or yoked feeding capacity
  • Activity monitoring in a home cage environment
  • Stress free body mass measurement in a home cage environment
  • Meal pattern analysis
  • Micro-event data acquisition for high-resolution analysis of ingestion and other behaviors

Human Research

  • Human room calorimetry
  • Activity monitoring

Sable Solutions

Promethion Core Metabolic System, Mouse

The Promethion Core High Definition Multiplexed Respirometry System for mice synchronously measures energy expenditure, RQ, VO2, VCO2 and activity.  The SableHD™ High Definition platform updates once per second for all sensors in ... (more)

Promethion High-Definition Room Calorimetry System

The Promethion High-Definition Room Calorimetry System is capable of synchronously recording all measured parameters in a completely traceable manner. Key components of this system include the GA-3m2 triple gas O2, CO2, and ... (more)

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Our systems are highly customizable for a broad range of applications. Let us help configure a system to meet your specific research needs.

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Relevant Publications

Publications Filter - Applications Page - Obesity

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75 Results Found (Showing 1 - 6)

Xanthohumol Pyrazole Derivative Improves Diet-Induced Obesity and Induces Energy Expenditure in High-Fat Diet-Fed Mice. Paraiso IL, Mattio LM, Alcázar Magaña A, Choi Jm Plagmann LS, Redick MA, Miranda CL, Maier CS, Dallavalle S, Kioussi C, Blakemore PR, Stevens JF. American Chemical Society. 11/4/2021.

November 4, 2021 12:00 am Published by Brett Davis

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Adipose expression of CREB3L3 modulates body weight during obesity. McCann MA, Li Y, Muñoz M, Gil V, Qiang G, Cordoba-Chacon J, Blüher M, Duncan S, Wee Liew C. Nature – Scientific Reports. 9/29/2021.

September 29, 2021 12:00 am Published by Brett Davis

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Endothelial BBsome is essential for vascular, metabolic, and retinal functions. Jiang J, Reho JJ, Bhattaarai S, Cherascu I, Hedberg-Buenz A, Meyer KJ, Tayyari F, Raukhorst AJ, Fu Guo D, Morgan DA, Taylor EB, Anderson MG, Drack AV, Rahmouni K. Molecular Metabolism. 7/23/2021.

July 23, 2021 12:00 am Published by Brett Davis

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Cajanolactone A, a stilbenoid from Cajamus cajan, inhibits energy intake and lipid synthesis/storage, and promotes energy expenditure in ovariectomized mice. Luo Z-H, Huang J-W, Meng Q-Q, Wu H-W, Yang R-Y, Fu L-C, Hu Y-J, Shen X-L. Biomedicine & Pharmacotheraphy. 3/18/2021.

March 18, 2021 12:00 am Published by Brett Davis

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Berberine modulates deacetylation of PPARy to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway. Xu Y, Yu T, Ma G, Zheng L, Jiang X, Yang F, Wang Z, Li N, He Z, Song X, Wen D, Kong J, Yu Y, Cao L. Bol Sci. 1/1/2021.

January 1, 2021 12:00 am Published by Brett Davis

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The aging mouse microbiome has obesogenic characteristics. Binyamin D, Werbner N, Nuriel-Ohayon M, Uzan A, Mor H, Abbas A, Ziv O, Teperino R, Gutman R, Koren O. Genome Medicine. 12/1/2020.

December 1, 2020 12:00 am Published by Brett Davis

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Sable Enables

Before configuring any system, we strive to understand your application. Our innovative instruments and analysis tools are then configured and customized for your application, providing you sound results and efficient workflow.

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