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Slide Circadian Studies

Applications

Home/Applications/Biomedical Research/Circadian Studies
Circadian StudiesBrett Davis2022-03-25T10:01:43-07:00

The circadian clock is crucial in many biological processes including energy balance. Long-term circadian disruptions are associated with premature mortality, obesity, impaired glucose tolerance, diabetes, psychiatric disorders, anxiety, depression, and cancer progression.  Short-term disruptions are associated with susceptibility to illness, fatigue, and loss of concentration, all of which effect quality of life, productivity, and lifespan.

Therefore, understanding how short- and long-term circadian disruptions affect the physiology of humans and animals will help to understand the etiology and progression of diseases as well as day-to-day well-being.

Important System Considerations

  • Food and water intake with automated access control; paired or yoked feeding capacity
  • Activity monitors
  • Running wheel
  • Environmental control of for light/dark cycle and temperature
  • Metabolic measurement capability (RER, VO2, VCO2)

Sable Solutions

Promethion Core Line

The new Promethion Core™ is the first and only metabolic and behavioral measurement system that utilizes modern digital and computer technology to deliver the highest resolution data regardless of study size. This ... (more)

CAB-8 and CAB-16 Environmental Control Cabinets

The CAB-8 and CAB-16 provide environmental control for your Promethion Core rodent metabolism and behavioral system. These cabinets provide up to 100 user-defined changes in temperature and light intensity over the course ... (more)

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Relevant Publications

Publications Filter - Applications Page - Circadian

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8 Results Found (Showing 1 - 6)

JARID1a Ablation in the Liver Alters Systemic Metabolism and Adaptation to Feeding. DiTacchio KA, Kalinowska D, Saran AR, Byrne A, Vollmers C, DiTacchio L. Cell Reports. 5/26/2020.

May 26, 2020 12:00 am Published by Brett Davis

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Western diet-induced obesity disrupts the diurnal rhythmicity of hippocampal core clock gene expression in a mouse model. Woodie LN, Johnsom RM, Ahmed B, Fowler S, Haynes W, Carmona B, Reed M, Vishnu S, Greene MW. Brain, Behavior, and Immunity. 5/20/2019.

May 20, 2019 12:00 am Published by Brett Davis

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Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron. Cedernaes J, Huang W, Ramsey KM, Waldeck N, Cheng L, Marcheva B, Omura C, Kobayashi Y, Peek CB, Levine DC, Dhir R, Awatramani R, Bradfield CA, Wang XA, Takahashi JS, Mokadem M, Ahima RS, Bass J. Cell Metabolism. 5/9/2019.

May 9, 2019 12:00 am Published by Brett Davis

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Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals. Adamovich Y, Ladeuix B, Sobel J, Manella G, Neufeld-Cohen A, Assadi MH, Golik M, Kuperman Y, Tarasiuk A, Koeners MP, Asher G. Cell Metabolism. 5/7/2019.

May 7, 2019 12:00 am Published by Brett Davis

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A rotating light cycle promotes weight gain and hepatic lipid storage in mice. Christie S, Vincent AD, Li H, Frisby CL, Kentish SJ, O’Rielly R, Wittert GA, Page AJ. American Journal of Physiology. 9/6/2018.

September 6, 2018 12:00 am Published by Brett Davis

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Time-Restricted Feeding Prevents Abalation of Diurnal Rhythms in Gastric Vagal Afferent Mechanosensitivity Observed in High-Fat Diet-Induced Obese Mice. Kentish SJ, Hatzinikolas G, Li H, Frisby CL, Wittert GA, Page AJ. The Journal of Neuroscience. 5/30/2018.

May 30, 2018 12:00 am Published by Brett Davis

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Sable Enables

Before configuring any system, we strive to understand your application. Our innovative instruments and analysis tools are then configured and customized for your application, providing you sound results and efficient workflow.

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