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Slide Neuroscience

Applications

Home/Applications/Physiology/Neuroscience
NeuroscienceJeff Richardson2022-03-25T10:17:25-07:00

Changes in neurological function may be produced by metabolic disease, neural injury, epigenetic causes, antibiotic history or exposure to toxins or treatments. Persistence and scientific rigor are a pre-requisite in this field where relevant patterns must be discerned from small signals. Metabolic assays and ethographic profiling of behavior are key methods when a high-definition, in-vivo record is required to evaluate efficacy in pharmaceutical safety, neurological or physiological investigations.

Important System Considerations

  • Second by second quantification of activity
  • Automated monitoring of food and water uptake amounts and event frequency
  • Differentiate between food uptake and food stashing
  • Differentiate between large ingested meals from micro meals
  • High-throughput capacity
  • Interchangeable instrumentation between mouse and rat cages
  • Compatibility with leading video analysis systems

Sable Solutions

Promethion Core Behavioral System, Mouse

The Promethion Core Behavior Phenotyping System features the modular flexibility to support real-time behavioral studies in a home-cage setting. Capture a complete data-rich archive of behaviors with unbeatable temporal resolution. Second-by-second observations ... (more)

Promethion Core Metabolic System, Mouse

The Promethion Core High Definition Multiplexed Respirometry System for mice synchronously measures energy expenditure, RQ, VO2, VCO2 and activity.  The SableHD™ High Definition platform updates once per second for all sensors in ... (more)

Rat GRID System

The new Promethion Rat GRID system provides automated analysis of ingestive behavior for up to 6 rats in a single spacious cage. Individual animal intake events are identified using RFID technology via ... (more)

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Relevant Publications

Publications Filter - Applications Page - Neuroscience

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May 14, 2023 3:44 pm Published by Brett Davis

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Loss of hypothalamic MCH decreases food intake in amyotrophic lateral sclerosis. Bolborea M, Vercruysse P, Daria T, Reiners JC, Alami NO, Guillot SJ, Dieterlé S, Sinniger J, Scekic-Zahirovic J, Londo A. Arcay H, Goy M, de Tapia CN, Thal DR, Shibuya K, Otani R, Arai K, Kuwabara S, Ludolph AC, Roselli F, Yilmazer-Hanke D, & Dupuis L. Acta Neuropathologica. 4/14/2023.

April 14, 2023 12:00 am Published by Brett Davis

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Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism.. Stark R, Dempsey H, Kleeman E, Sassi M, Davies J, Zigman JM, & Andrews ZB. bioRxiv. 1/27/2023.

January 27, 2023 12:00 am Published by Brett Davis

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CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model. Johnson NR, Yuan P, Castillo E, Lopez TP, Yue W, Bond A, Rivera BM, Sullivan MC, Hirouchi M, Giles K, Aoyagi A, & Condello C. Nature Communications. 1/9/2023.

January 9, 2023 12:00 am Published by Brett Davis

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Liver-Secreted Hexosaminidase A Regulates Insulin-Like Growth Factor Signalling and Glucose Transport in Skeletal Muscle. Montgomery MK, Bayliss J, Nie S, de Nardo W, Keenan SN, Anari M, Taddese AZ, Williamson NA, Ooi GJ, Brown WA, Burton PR, Gregorevic P, Goodman CA, Watt KI, & Watt MJ. American Diabetes Association – Metabolism. 12/29/2022.

December 29, 2022 12:00 am Published by Brett Davis

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Diet containing stearic acid increased food intake in mice by reducing serum leptin compared with oleic acid. Zhu S, Feng Xiaohua, Feng Xiajie, Xie K, Li Y, Chen L, Mo Y, Liang J, Wu X, Sun Z, Shu G, Wang S, Gao P, Zhu X, Zhu C, Jiang Q, & Wang L. Food & Function. 12/22/2022.

December 22, 2022 12:00 am Published by Brett Davis

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Sable Enables

Before configuring any system, we strive to understand your application. Our innovative instruments and analysis tools are then configured and customized for your application, providing you sound results and efficient workflow.

What's New

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    John Lighton, PhD – How he founded Sable Systems and revolutionized the measurement of metabolism

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