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Home/Products/Promethion Core Line/Promethion Core Metabolic System, Rat
Promethion Core Metabolic System, RatBrett Davis2022-12-22T09:26:16-08:00
Promethion Core Metabolic System, Rat

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Rat cage with food, water and running wheel

Features

  • Highest resolution gas analyzers (O2 and CO2 standard; 13CO2, and CH4 optional)
  • Comprehensive activity measurements including running, eating, and drinking
  • Compatible with telemetry, optogenetic, and other 3rd party equipment
  • Elegant design that minimizes footprint while maximizing simplicity of use
  • Real-time system monitoring & experiment analysis by Promethion Live software

Description

The Promethion Core Metabolic System gives you the truest and most trustworthy results from your rat phenotyping studies. At the heart of the system is the highest resolution metabolic measurement instrumentation, yielding accurate resting and active energy expenditure values.

Then we add second-by-second behavioral measurements, providing the highest data granularity. Promethion Core tightly synchronizes all data (metabolic and behavioral), allowing you to pinpoint and correlate metabolic change with each behavioral event.  All the raw data is saved for further data mining.

Other systems try to match Promethion Core’s performance by employing an oversampling technique, for example, continuous gas measurements of each cage. But due to these systems’ low-resolution gas analyzers and requisite slow air-exchange rates, continuous oversampling simply results in useless and redundant data (see video “The Effects of Cage Air-Flow Rate”).

The system is expandable to measure, in real time, gut microbiome methane production with our methane analyzer, fuel utilization research with our stable isotope gas analyzer, and temperature/light-controlled studies with our Environmental Control Cabinet. You can even  connect 3rd party equipment such as telemetry and optogenetic systems.

The entire system is compact and self-contained to save valuable lab space, allowing up to 8 cages in an environmental cabinet. Your workflow is efficient with swappable components and magnetic mounts for quick exchange of food hoppers and water bottles.

The new Promethion Live software enables you to control all aspects of your study. The simplified interface maximizes experiment success with intuitive system and experiment setup. One-step gas calibration ensures accurate respirometry measurements. Status indicators for vital components verify system performance. Constant monitoring of all parameters means you will always know the well-being of each animal. Routine experiment configurations can be easily saved and reused.

With Promethion Live, you can explore comparative trends during an experiment looking at every parameter measured, such as running speed, food consumed, or energy expended (data shown). The software uniquely provides the mean (± SD; ± SEM) or median of grouped data for real-time statistical comparison and experiment evaluation. You’re empowered with the real-time experiment and animal information needed to make key decisions at any time, from any place.

Key Components

  • Promethion Core Instrumentation includes:
    • Triple Gas Single Path Analyzer
    • 8-channel Flow Generator and Multiplexer
    • Promethion Live onboard computer and memory
  • Standard size home cage
  • Precision Mass Monitors
  • Magnetic Mount Food Hopper
  • Magnetic Mount Water Bottle with Sipper Tube
  • 2- or 3-Dimensional Infrared Beam Break Array
  • Promethion Live Software Platform
  • Desktop Computer with Monitor

Optional Components

  • Body Mass Habitat
  • Running Wheel
  • Access Control Door for Food Hopper
  • Environmental Sensor Array
  • Environmental Control Cabinet
  • Telemetry Bases for Body Temperature and Heart Rate
  • Stable Isotope Analyzer (13CO2)
  • Methane Analyzer
  • Optogenetic Compatible Cage Lid

Contact Us

For a custom configuration, contact us and our specialists will help you configure the right system for your specific research needs.

Downloads

Promethion Core brochure
Promethion Live Software brochure
Environmental Control Cabinet

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Promethion Core Line

Menu   ≡ ╳
  • Promethion Core Overview
  • Systems
    • Promethion Core Metabolic System, Mouse
    • Promethion Core Behavioral System, Mouse
    • Promethion Core Metabolic System, Rat
    • Promethion Core Behavioral System, Rat
    • GRID System, Rat
  • Cages and Monitoring
    • Sable Metabolic Treadmill
    • Cages (Standard and ISO)
    • Total Activity (ADX, XYZ beam break)
    • Wheel Activity
    • Food and Water
    • Body Mass
  • Data Acquisition and Analysis
    • Promethion Live Software Platform
  • Flow Generators and Gas Analyzers
    • Flow Generators and Gas Analyzers
    • Promethion Methane Gas Analyzer
    • Stable Isotope Gas Analyzer
  • Environmental Control and Monitoring
    • CAB-8 and CAB-16 Environmental Control Cabinets
    • ESA Environmental Sensor Array

Sable Enables

Trust In Your Data – Exclusive SableHD™ high-definition digital technology provides industry-leading accuracy, highest sampling rate, and unbeatable resolution of rapidly changing metabolic data. And you get the full benefits of Promethion technology, including preservation of raw data, water vapor compensation, pull mode indirect calorimetry and the Sable home cage advantage.

Confidence in Your Experiments – Promethion Core system stability and precision provide comparable data year after year. This enables longitudinal studies over the life span of your mice or rats.

Actionable Intelligence – Promethion Live software empowers you with real-time animal and system information needed to make key decisions at any time from your authorized desktop or mobile device. If the health and welfare of an animal changes, you’ll know the moment it happens.  By monitoring activity, ingestive behavior and weight change, you know when to make adjustments. Continuous monitoring of all system components empowers you with total experimental control.

More with Less – High resolution centralized analyzers and innovative design give Promethion Core™ the ability to run more metabolic cages at a lower cost. The compact design saves valuable lab space.

Ease of Maintenance –Quickly turnaround experiments using saved prior configurations as templates for new studies. Innovative design provides efficient animal management, cage maintenance, and system cleaning.

What's New

  • In searching for biological origins of obesity, Louisiana lab goes back to the beginning of life

    In searching for biological origins of obesity, Louisiana lab goes back to the beginning of life

    June 23, 2022
  • Calculating the rate for oxidation for 13C breath tracers

    Calculating the rate for oxidation for 13C breath tracers

    April 13, 2022
  • High Precision Methane Measurement

    High Precision Methane Measurement

    April 2, 2022
  • Sable Announces the Release of New Metabolic Treadmill for Mice

    Sable Announces the Release of New Metabolic Treadmill for Mice

    February 16, 2022

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