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Continuous Metabolic Phenotyping – How Continuous is “Continuous”?

A continuous metabolic phenotyping system is required for tracking rapid changes in metabolic data. Such a metabolic phenotyping system must sample continuously from each cage in parallel. Because each cage gets its own gas analyzer system, the sampling rate can be greatly increased relative to multiplexed systems, which share a gas analyzer chain between several [...]

Published on January 12th, 2014|Founder's Blog, Latest Blog Post|

Sex, lies, and water vapor

OK, don’t get your hopes up. This will be the last mention of sex in this blog entry. However, we will deal at length with lies and water vapor, especially lies (OK, OK, let's just call it simple misunderstandings) about the feasibility of using direct water vapor measurement to correct mathematically for the dilution effects [...]

Published on October 7th, 2013|Founder's Blog|

Tiny Food Intake Events (Micro-Intakes) Can be Important!

Many food intake events (= food uptake events) are too small for legacy "food intake measurement systems" or metabolic phenotyping systems to detect. Each of these feeding events corresponds to a neurological signal to feed, even if the actual amount is small. As such, they convey important behavioral information. I can easily imagine a gene [...]

Published on August 28th, 2013|Founder's Blog|

Combining a metabolic cage (with urine and feces collection) and respirometry: It’s easy!

In some fields of research, a difficult balancing act exists between answering different questions. For example, a researcher may need to measure metabolic rates, while also needing quantitative measurements of urine and feces output.  Measuring compounds in the urine is often key to understanding questions such as the biochemical pathways by which drugs are metabolized, [...]

Published on August 8th, 2013|Founder's Blog|

Distinguishing individual food uptake in communally housed mice using RFID

Mice are communal beasts, just like rats. They live in groups, and separating them - as required for measuring food intake / food uptake or energy expenditure - stresses them, elevating cortisol levels and leading to to a host of unwanted side-effects. Using the right technology, however, obtaining separate food uptake recordings from communally housed [...]

Published on July 10th, 2013|Founder's Blog|

A solution for bulk photosynthetic efficiency screening

Sometimes strange ideas come into my head. Most of the time, being too busy to act on them, I shoo them away and get on with my life. On this one occasion, though, we had a continuous metabolic measurement system already set up, and were about to use it for measuring the metabolic rate of a rat. [...]

Published on March 22nd, 2013|Founder's Blog|

The “Deep Data Field System” in Metabolic Phenotyping

Data from a metabolic phenotyping system can be rigidly determined by the parameters entered at the time of the experiment (as with legacy systems), or the data can be a rich mine of information, with complete post-hoc analytical flexibility (as with Promethion). The latter approach allows extraction of experimental data, the need for which was not [...]

Published on January 29th, 2013|Founder's Blog|

Activity Metabolism Measurements Made Easy in Metabolic Phenotyping

One of the classic controversies in the field of metabolic science is the effect of activity on overall energy expenditure. As a comparative physiologist with a long-standing interest in energetics (and several papers published in that field), I find this controversy to be particularly strange, especially because some respectable and intelligent people will politely insist [...]

Published on October 30th, 2012|Founder's Blog|