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Slide Neuroscience

Applications

Home/Applications/Biomedical Research/Neuroscience
NeuroscienceJeff Richardson2022-03-25T10:17:30-07:00

Changes in neurological function may be produced by metabolic disease, neural injury, epigenetic causes, antibiotic history or exposure to toxins or treatments. Persistence and scientific rigor are a pre-requisite in this field where relevant patterns must be discerned from small signals. Metabolic assays and ethographic profiling of behavior are key methods when a high-definition, in-vivo record is required to evaluate efficacy in pharmaceutical safety, neurological or physiological investigations.

Important System Considerations

  • Second by second quantification of activity
  • Automated monitoring of food and water uptake amounts and event frequency
  • Differentiate between food uptake and food stashing
  • Differentiate between large ingested meals from micro meals
  • High-throughput capacity
  • Interchangeable instrumentation between mouse and rat cages
  • Compatibility with leading video analysis systems

Sable Solutions

Promethion Core Behavioral System, Mouse

The Promethion Core Behavior Phenotyping System features the modular flexibility to support real-time behavioral studies in a home-cage setting. Capture a complete data-rich archive of behaviors with unbeatable temporal resolution. Second-by-second observations ... (more)

Promethion Core Metabolic System, Mouse

The Promethion Core High Definition Multiplexed Respirometry System for mice synchronously measures energy expenditure, RQ, VO2, VCO2 and activity.  The SableHD™ High Definition platform updates once per second for all sensors in ... (more)

Rat GRID System

The new Promethion Rat GRID system provides automated analysis of ingestive behavior for up to 6 rats in a single spacious cage. Individual animal intake events are identified using RFID technology via ... (more)

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Relevant Publications

Publications Filter - Applications Page - Neuroscience

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23 Results Found (Showing 13 - 18)

Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adapation to calorie restriction. Reichenbach A, Stark R, Mequinion M, Lockie SH, Lemus MB, Mynatt RL, Luquet S, Andrews ZB. The Journal of the Federation of American Societies for Experimental Biology. 6/22/2018.

June 22, 2018 12:00 am Published by Brett Davis

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Neuromodulation of orexin neurons reduces diet-induced adiposity. Zink AN, Bunney PE, Holm AA, Billington CJ, Kotz CM. International Journal of Obesity. 4/10/2018.

April 10, 2018 12:00 am Published by Brett Davis

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NCB5OR Deficiency in the Cerebellum and Midbrain Leads to Dehydration and Alterations in Thirst Response, Fasted Feeding Behavior, and Voluntary Exercise in Mice. Stroh MA, Winter MK, McCarson KE, Thyfault JP, Zhu H. Cerebellum. 4/1/2018.

April 1, 2018 12:00 am Published by Brett Davis

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Chronic infusion of taurolithocholate into the brain increases fat oxidation in mice. Eggink HM, Tambyrajah LL, van den Berg Rosa, Mol IM, van den Heuvel JK, Koehorst M, Groen AK, Boelen A, Kalsbeek A, Romijn JA, Rensen PCN, Kooijman S, Soeters MR. Journal of Endocrinology. 2/1/2018.

February 1, 2018 12:00 am Published by Brett Davis

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Dopamine Neuron-Restricted Leptin Receptor Signaling Reduces Some Aspects of Food Reward but Exacerbates the Obesity of Leptin Receptor-Deficient Male Mice. Evans MC, Anderson GM. Endocrinology. 8/18/2017.

August 18, 2017 12:00 am Published by Brett Davis

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A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding. Dodd GT, Andrews ZB, Simonds SE, Michael NJ, DeVeer M, Brüning JC, Spanswick D, Cowley MA, Tiganis T. Cell Metabolism. 8/1/2017.

August 1, 2017 12:00 am Published by Brett Davis

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Sable Enables

Before configuring any system, we strive to understand your application. Our innovative instruments and analysis tools are then configured and customized for your application, providing you sound results and efficient workflow.

What's New

  • In searching for biological origins of obesity, Louisiana lab goes back to the beginning of life

    In searching for biological origins of obesity, Louisiana lab goes back to the beginning of life

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  • Calculating the rate for oxidation for 13C breath tracers

    Calculating the rate for oxidation for 13C breath tracers

    April 13, 2022
  • High Precision Methane Measurement

    High Precision Methane Measurement

    April 2, 2022
  • Sable Announces the Release of New Metabolic Treadmill for Mice

    Sable Announces the Release of New Metabolic Treadmill for Mice

    February 16, 2022

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