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Slide Neuroscience

Applications

Home/Applications/Biomedical Research/Neuroscience
NeuroscienceJeff Richardson2022-03-25T10:17:30-07:00

Changes in neurological function may be produced by metabolic disease, neural injury, epigenetic causes, antibiotic history or exposure to toxins or treatments. Persistence and scientific rigor are a pre-requisite in this field where relevant patterns must be discerned from small signals. Metabolic assays and ethographic profiling of behavior are key methods when a high-definition, in-vivo record is required to evaluate efficacy in pharmaceutical safety, neurological or physiological investigations.

Important System Considerations

  • Second by second quantification of activity
  • Automated monitoring of food and water uptake amounts and event frequency
  • Differentiate between food uptake and food stashing
  • Differentiate between large ingested meals from micro meals
  • High-throughput capacity
  • Interchangeable instrumentation between mouse and rat cages
  • Compatibility with leading video analysis systems

Sable Solutions

Promethion Core Behavioral System, Mouse

The Promethion Core Behavior Phenotyping System features the modular flexibility to support real-time behavioral studies in a home-cage setting. Capture a complete data-rich archive of behaviors with unbeatable temporal resolution. Second-by-second observations ... (more)

Promethion Core Metabolic System, Mouse

The Promethion Core High Definition Multiplexed Respirometry System for mice synchronously measures energy expenditure, RQ, VO2, VCO2 and activity.  The SableHD™ High Definition platform updates once per second for all sensors in ... (more)

Rat GRID System

The new Promethion Rat GRID system provides automated analysis of ingestive behavior for up to 6 rats in a single spacious cage. Individual animal intake events are identified using RFID technology via ... (more)

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Relevant Publications

Publications Filter - Applications Page - Neuroscience

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23 Results Found (Showing 19 - 23)

Type 3 Deiodinase Role on Central Thyroid Hormone Action Affects the Leptin-Melanocortin System and Circadian Activity. Wu Z, Elena Martinez M, St. Germain DL, Hernandez A. Endocrinology. 12/2/2016.

December 2, 2016 12:00 am Published by Brett Davis

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High fat diet induces brain insulin resistance and cognitive impairment in mice. Kothari V, Luo Y, Tornabene T, O’Neill AM, Greene MW, Geetha T, Babu JR. Biochemica et Biophysica Acta. 10/19/2016.

October 19, 2016 12:00 am Published by Brett Davis

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Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. Cui J, Ding Y, Chen S, Zhu X, Wu Y, Zhang M, Zhao Y, Li T-RR, Sun LV, Zhao S, Zhuang Y, Jia W, Han M, Xu T, Wu X. The Journal of Clinical Investigation. 9/1/2016.

September 1, 2016 12:00 am Published by Brett Davis

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Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response. Wang Q-P, Qi Lin Y, Zhang L, Wilson YA, Oyston LJ, Cotterell J, Qi Y, Khuong TM, Bakhshi N, Planchehault Y, Browman DT, Tat Lau M, Cole TA, Wong ACN, Simpson SJ, Cole AR, Penninger JM, Herzog H, Gregory Neely G. Cell Metabolism. 7/12/2016.

July 12, 2016 12:00 am Published by Brett Davis

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Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fad rats by enhancing satiety responses and increasing lipid utilization. Blevins JE, Thompson BW, Anekonda VT, Ho JM, Graham JL, Roberts ZS, Hwang BH, Ogimoto K, Wolden-Hanson T, Nelson J, Kaiyala KJ, Havel PJ, Bales KL, Morton GJ, Schwarts MW, Baskin DG. American Journal of Physiology. 1/20/2016.

January 20, 2016 12:00 am Published by Brett Davis

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Sable Enables

Before configuring any system, we strive to understand your application. Our innovative instruments and analysis tools are then configured and customized for your application, providing you sound results and efficient workflow.

What's New

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